Ph.D. Deepak Kumar Bhalla
(313) 577-3980
Deepak.Bhalla@wayne.edu
PROFESSIONAL POSITIONS:
1976-1979:Postdoctoral Fellow, Department of Pathology, Harvard Medical School, Boston, MA.
1979-1982:Assistant Research Cell Biologist, Department of Medicine, University of California Medical Center, San Francisco, and Cell Biology Section, V.A. Medical Center, San Francisco, CA.
1982-1986:Assistant Professor, Dept. of Comm. & Environ. Med., University of California, Irvine, CA.
1986-1995:Associate Professor, Dept. of Comm. & Environ. Med., University of California, Irvine, CA.
1995-1998:Associate Professor, Dept. of Occup. & Environ. Health Sci., Wayne State University, Detroit, MI.
2000-2001: Professor and Acting Chair, Dept of Occup. & Environ. Health Sci, Wayne State University.
1998 - Present:Professor, Dept. of Occup. & Environ. Health Sci., Wayne State Univ., Detroit.
Joint appointment inDept of Pharmaceutical Sciences and Karmanos Cancer Institute.
PROFESSIONAL ACTIVITIES:
1992-1997:Toxicology Study Section, National Institutes of Health.
1993-1994:Consultant, Revision of the air quality criteria document for ozone, U. S. E. P. A.
1994: Editorial Board, Inhalation Toxicology
1994:Study Section/Program Project Applications, National Institute of Environmental Health Sciences
1997: Harvard Center Grant review and site visit, National Institute of Environmental Health Sciences.
2000:Guest Editor, Journal of Toxicology and Environmental Health
2000:Adhoc Study Section, National Institutes of Health.
2001: U.C. Davis Center Grant review and site visit, National Institute of Environmental Health Sciences.
2001:ALTX-4 Study Section, National Institutes of Health.
1999-2002:Editorial Board, Journal of Toxicology and Environmental Health
2002: Harvard Center Grant review and site visit, NIEHS
2003: Consultant, Revision of the air quality criteria document for ozone, U. S. E. P. A
Punjab University, Chandigarh, India B.Sc. Biology 1968
Punjab University, Chandigarh, India M.Sc. Cell Biology 1969
Howard University, Washington, D.C. Ph.D. Cell Biology 1976
Harvard Medical School, Boston, MA Post-doc. Cell Biology 1976-79
Bhalla, D.K., Rasmussen, R.E. and Daniels, D. Adhesion and motility of polymorphonuclear leukocytes isolated from the blood of rats exposed to ozone: potential biomarkers of toxicity. Tox. Appl. Pharm., 123(2):177-186, 1993.
Ziegler, B., Bhalla, D.K., Rasmussen, R.E., Kleinman, M.T. and Menzel, D.B. Inhalation of resuspended road dust, but not ammonium nitrate, decreases the expression of the pulmonary macrophage Fc receptor. Tox. Lett., 71: 197-208, 1994.
Bhalla, D.K. Alteration of ozone induced airway permeability by oxygen metabolites and anti-oxidants. Tox. Lett., 73: 91-101, 1994.
Wong, C.G., Bonakdar, M., Kleinman, M.T. Chow, J. and Bhalla, D.K. Elevation of stress-inducible heat shock protein 70 in the rat lung after exposure to ozone and particle containing atmospheres. Inhal. Tox., 6: 501-514, 1994.
Kleinman, M.T., Bhalla, D.K., Mautz, W.J., and Phalen, R.F. Cellular and immunologic injury with PM10 inhalation. Inhal. Tox., 7:589-602, 1995.
Ma, T.Y., Hollander, D., Tran, L.T., Nguyen, D., Hoa, N. and Bhalla, D.K. Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability. J. Cell. Physiol., 164:533-545, 1995.
Young, C. and Bhalla, D.K. Effects of ozone on the epithelial and inflammatory responses in the airways: Role of Tumor Necrosis Factor. J. Tox. Environ. Health, 46: 329-342, 1995.
Kleinman, M.T., Bhalla, D.K., Mautz, W.J., and Phalen, R.F. Cellular and immunologic injury with PM10 inhalation. Proc. Colloq. Particulate Air Pollution and Human Mortality and Morbidity, 427-449, 1995.
Hallman, M., Waffarn, F., Turbow, R., Bry, K., Kleinman, M.T, Mautz, W.J., Rasmussen, R.E., BhallaD.K. and
Phalen, R.F. Surfactant dysfunction after inhalation of nitric oxide. J. Appl. Physiol., 80(6): 2026-2034, 1996.
Bhalla, D.K. Toxicologic effects of ozone and related photochemical oxidants: lung inflammation and
permeability changes. EPA Air Quality Criteria for Ozone and Related Photochemical Oxidants, III: 620-636,1996.
Bhalla, D.K. Alteration of alveolar macrophage chemotaxis, cell adhesion and cell adhesion molecules following ozone exposure of rats. J. Cell. Physiol., 169: 429-438, 1996.
Bhalla, D.K., Hoffman, L. and Pearson, A.C. Modification of macrophage adhesion by ozone: Role of cytokines and cell adhesion molecules. Ann. N.Y. Acad. Sci., 796: 38-46, 1996.
Bhalla, D.K. Specialized sampling techniques. In Methods in Inhalation Toxicology, R.F. Phalen (ed.) CRC Press,pp 125-145, 1996.
Pearson, A. and Bhalla, D.K. Effects of ozone on early inflammatory events in the rat lung: Modification of macrophage adhesion. J. Tox. Environ. Health., 50:143-157,1997.
Bolarin, D.M., Bhalla, D.K. and Kleinman, M.T. Effects of repeated exposures of geriatric rats to ozone and particle-containing atmospheres: An analysis of bronchoalveolar lavage and plasma proteins. Inhal. Tox., 9: 423-434, 1997.
Bhalla, D.K. and Hoffman, L. Time course of airway epithelial and inflammatory changes in rats exposed to moderate levels of ozone. Inhal. Tox., 9: 829-842, 1997.
Gupta, S.K. Reinhart, P.G. and Bhalla, D.K. Enhancement of fibronectin expression in rat lung by ozone and an inflammatory stimulus. Amer. J. Physiol. (Lung Cell Mol. Physiol.), 275 (19): L-330-335, 1998.
Reinhart, P.G. and Bhalla, D.K. The influence of polymorphonuclear leukocytes on altered pulmonary epithelial permeability during ozone exposure. Toxicology 127: 17-28, 1998.
Bhalla, D.K. Ozone induced lung inflammation and mucosal barrier disruption: Toxicology, mechanisms and implications. J. Tox. Environ. Health (B) , 2: 31-86, 1999.
Bhalla, D.K., Gupta, S.K. and Reinhart, P.G. Alteration of epithelial integrity, alkaline phosphatase activity and
fibronectin expression in lungs of rats exposed to ozone. J. Tox Environ. Health., 56: 101-115, 1999.
Bhalla, D.K. Evaluation of wound repair mechanisms using an in vitro cell culture model. (Editorial). J. Lab. Clin. Med., 134: 1-2, 1999.
Reinhart, P.G., Gupta, S.K. and Bhalla, D.K. Attenuation of ozone-induced lung injury by IL-10. Tox. Lett., 110:35-42, 1999.
Bhalla, D.K. and Gupta, S.K. Lung injury, inflammation and inflammatory stimuli in rats exposed to ozone. J. Tox.
Environ. Health, 59:101-118, 2000.
Bassett, D.J.P. and Bhalla, D.K. Inflammation and fibrosis. In Pulmonary Immunotoxicology, M. Cohen, J. Zelikoff and R. Schlesinger (Editors). Kluwer Academic Publishers, Norwell, MA, 127-151, 2000.
Bhalla, D.K. and Gupta, S.K. Lung injury, inflammation and inflammatory stimuli in rats exposed to
ozone. J. Tox. Environ. Health, 59:101-118, 2000.
Kleinman, M.T., Bufalino, C., Rasmussen, R., Hyde, D., Bhalla, D.K. and Mautz, W.J. Toxicity of chemical components of ambient fine particulate matter (PM 2.5) inhaled by aged rats. J. Applied Tox., 20 (5): 357-364, 2000.
Bhalla, D.K. Oxidative effects and inflammatory responses in the lung. J. Tox. Environ. Health, 61 (1):3-8, 2000 Mautz, W.J. Kleinman, M.T., Bhalla, D.K. and Phalen, R.F. Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture. Tox. Sci., 61: 331-341, 2001.
Bhalla, D.K., Reinhart, P.G., Bai, C. and Gupta, S.K. Amelioration of ozone-induced lung injury by anti-tumor necrosis factor alpha. Tox. Sci. 69: 400-408, 2002.
Bhalla, D.K. Interactive effects of cigarette smoke and ozone in the induction of lung injury. Tox. Sci., 65: 1-3, 2002.
Kleinman, M.T., Hyde, D., Bufalino, C., Basbaum, R., Bhalla, D.K. and Mautz, W.J. Toxicity of chemical components of fine particles inhaled by aged rats: Effects of concentration. J. Air Waste Mgmt. Assoc. 53 (9): 1080 - 1087, 2003.
Bhalla, D.K. and Warheit, D. B. Biological agents with potential for misuse: a historical perspective and defensive measures. Tox. Appl. Pharm. 199 (1): 71-84, 2004.
Bhalla, D.K. Toxicologic effects of ozone and related photochemical oxidants: lung inflammation and permeability changes. EPA Air Quality Criteria for Ozone and Related Photochemical Oxidants. EPA 600/R-05/004aF, I: 522-532, 2006.
Cigarette Smoke and Ozone Induced Inflammatory Lung Injury