Wayne State University

Aim Higher

Faculty Biography
 

George B. Corcoran PhD


(313) 577-1737(313) 577-1737

corcoran@wayne.edu
EACPHS Room 3615

Appointments

Chair and Professor, Department of Pharmaceutical Sciences



Education Training

1970  BA Chemistry, Department of Chemistry, Ithaca College, Ithaca, NY

1973  MS Chemistry, Department of Chemistry, Bucknell University, Lewisburg, PA

1980  PhD Pharmacology with Minor In Biochemistry, Department of Pharmacology,

               School of Medicine, George Washington University, Washington, DC

1981  Postdoctoral Fellowship in Toxicology, Pharmacology/Toxicology Program,

               Department of Medicine, Baylor College of Medicine, Houston, TX


Positions and Employment

CURRENT POSITIONS, TITLES, AFFILIATIONS

1996   Professor & Chairman, Dept of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI

1999    Adjunct Professor, Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI

2004    Member, Academy of Toxicological Sciences Member

2013    Member, WSU Michigan Translational Research and Commercialization Oversight Committee

2012    Member, Executive Board, Academy of Toxicological Sciences

2012    Member, National Toxicology Program Board of Scientific Counselors

2011    Member, Advisory Board, WSU Nano Incubator Program

2011    Member, Executive Board, Association of Medical School Pharmacology Chairs

2004    Visiting Professor, Addis Ababa School of Medicine, Addis Ababa, Ethiopia

2002    Associate Editor, Toxicology and Applied Pharmacology

1997    Member, Graduate Faculty, Wayne State University, Detroit, MI

2009    Member, Advisory Board, Institute for Environmental Health Sciences, Wayne State University

1996    Member, Institute for Environmental Health Sciences, Wayne State University

1996    Member, Barbara Ann Karmanos Cancer Institute, Wayne State University, Setroit, MI

 
PREVIOUS POSITIONS, TITLES, AFFILIATIONS

2012-13     Past Chair, Executive Board, Council of Scientific Society Presidents

2007-13     Member, Executive Board, Council on Scientific Societies Presidents

2007-13     Member, WSU Clinical Translational Science Award (CTSA) Steering Committee (MACTS)

2007-13     Director, WSU CTSA Novel Clinical and Translational Methodologies

2002-12     Member, Editorial Board, Basic and Clinical Pharmacology and Toxicology

2008-11     Member, Scientific Advisory Committee on Alternative Toxicological Methods (SACATM)

2008-09     Past President, Society of Toxicology

2007-08     President, Society of Toxicology

2006-07     Vice President, Society of Toxicology

2005-06     Vice President-Elect, Society of Toxicology

2004-10     Councilor, International Union of Toxicology

2003-09     Member, US Environmental Protection Agency Scientific Advisory Board, Exposure and Human Health Committee

2003-09     Member, US Environmental Protection Agency FIFRA Scientific Advisory Panels

2004-06     Member, US EPA FIFRA N-Methyl-Carbamates Scientific Advisory Panel

2004-06     Member, US EPA SAB Perfluorooctanoic Acids Scientific Advisory Panel

2003-06     Member, US EPA SAB PPAR-alpha Scientific Advisory Panel

2003-05     Member, The National Academies Vietnam Education Foundation Fellowships Panel

2002-03     Chairman, The National Academies National Research Council Hughes Pre-Doctoral Fellowships Neurology and Physiology 1 Panel,  Member 2000-03

2001-03     Secretary, Society of Toxicology

1999-04     Member, Steering Committee, John D. Dingell VA Diabetes Research Enhancement Award Program, Detroit, MI

1998-06     Member, Advisory Board, Children’s Center for Clinical Pharmacology, Children’s Hospital of MI

1996-02     Member, Alcohol Toxicology-1 Study Section, National Institutes of Health, Bethesda, MD

1996-02     Member, Program Leaders Group, Karmanos Cancer Institute, Wayne State University, Detroit, MI

2000-01     Secretary-Elect, Society of Toxicology

1999-07     Member, John D. Dingell VA Research & Development Committee

1997-99     Member, Scientific Council, American Society for Pharmacology and Experimental Therapeutics

1996-98     Chairman, Division of Toxicology Executive Committee, American Society for Pharmacology Experimental Therapeutics

1997-99     Member, Human Genetics Program Advisory Group, Wayne State University

1996-08     Member, National Institute of Environmental Health Sciences Center for Molecular & Cellular Toxicology with Human Applications, Wayne State University, Detroit, MI

1993-97     Member, Editorial Board, Toxicology Letters

1993-96     Member, Editorial Board, Toxicology and Applied Pharmacology

1993-97     Professor of Pharmacology & Toxicology, Basic Pharmaceutical Sciences, University of New Mexico College Pharmacy, Albuquerque, NM

1992-98     Member, Editorial Board, Journal of Toxicology and Environmental Health

1989-96     Chairman, Toxicology Graduate Program, University of New Mexico College of PharmacyAlbuquerque, NM

1993-96     Adjunct Professor, Dept of Biochemistry, Univeristy of New Mexico School of Medicine, Albuquerque, NM

1992-96     Faculty Affiliate, Center on Alcoholism, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, NM

1990-93     Adjunct Associate Professor, Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque, NM

1988-93     Associate Professor of Pharmacology and Toxicology, Basic Pharmaceutical Sciences, University of New Mexico College Pharmacy, Albuquerque, NM

1981-88     Assistant Professor, Department of Pharmaceutics, School of Pharmacy, SUNY at Buffalo, Buffalo, NY

1980-81     Senior Research Scientist, The Methodist Hospital, Texas Medical Center, Houston, TX

1977-80     Research Assistant, Department of Medicine, Baylor College of Medicine, Houston, TX

1974-77     Chemist (Federal Civil Servant), National Heart and Lung Institute, National Institutes of Health, Bethesda, MD

1972-74     Guest Worker, National Heart and Lung Institute, National Institutes of Health, Bethesda, MD

1970          Visiting Chemist, Sun Oil Company, Marcus Hook, PA

1970-72     Graduate Teaching Assistant, Department of Chemistry, Bucknell University, Lewisburg PA


Other Experience Professional Memberships

Memberships, Fellowships, and Offices Held in Professional Organizations

1966  Zeta Sigma Nu Honor Society

1968  American Chemical Society (Student Affiliate - Currently Inactive)

1982  American Association for the Advancement of Science (Currently Inactive)

1984  Pharmacy School Pharmacologists (Currently Inactive)

1986  American Association of Pharmaceutical Scientists (Charter Member, Currently Inactive)

1987  American Society for Pharmacology and Experimental Therapeutics

            Scientific Council: Member (1997-9)

            Division of Drug Metabolism: Member (1988-)

            Division of Toxicology: Member (1991-)

            Division of Toxicology Executive Committee: Chair (1997-9), Member (1996-00)

  1988  Society of Toxicology

           Board of Directors (Council), Chair (2007-2008), Member (2001-2004; 2005-2009)

        Congressional Subcommittee, Chair (2008-2013), Member (2007-date)

        Nominating Committee, Chair (2009), Member (2013-14)

        Undergraduate Education Strategic Work Group, Member (2012-Date)

        Endowment Fund Board, Member (2007-2010)

        Finance Committee, Member (2006-2009)

        Board of Publications, Member (2006-2009); Marketing Subcommittee (2006-2009)

        Membership Services Strategy Committee, Council Liaison (2006-2007)

        Nominating Committee, Council Liaison (2005-2006)

        Program Committee, Chair (2006-2007), Co-Chairman (2005-2006)

        Post-Doctoral Fellow Task Force, Council Liaison (2005-2006)

        Placement Committee, Chair (1992-193); Member (1990-1993); Volunteer (1989-1990)

        Education Committee, Chair (1995-1996); Member (1993-1996)

            Sub-Committee on Community Outreach, Member (1996-1998)  

            Subcommittee on Minority Education Initiatives, Inaugural Chair (1995-1996)

        Mechanisms Specialty Section Elected Councilor (1996-1998), Member (1988-Date)

        Regulatory and Safety Evaluation Specialty Section Member (1993-Date)

1988  Mountain West Chapter of the Society of Toxicology

            Vice President Elect (1996-7); Treasurer (1993-4); Secretary/Treasurer (1991-3); Local

            Organizing Comm Chairperson (1989); Awards Committee (1990, 1994); Member (1988-97)

  1997  Michigan Chapter of the Society of Toxicology Member (1997-)

1988  American Association of Colleges of Pharmacy (1992-), Volwiler Award Committee Member (1997-8)

1993  International Union of Pharmacology

            Section on Toxicology, Vice President  (1994-1998), President (1998-02)

  1999  Michigan Pharmacists Association Member (1999-Date)

  2004  International Union of Toxicology

            Candidate, Secretary-General (2004, 2007) 

            Councilor (2005-2008, 2008-2011)

OTHER SERVICE TO THE PROFESSION (Also See Present and Past Affiliations)

Society of Toxicology

     Symposium Organizer, Chair, Skeptically Re-Examining the Limits of Toxicology Evidence in the Courtroom (2014)

          Symposium Organizer, Chair, SOT as a Resource for Congress on Emerging Issues: The Congressional

          Subcommittee Presents a Socratic Debate on Hydraulic Fracturing (2014)

     Roundtable Organizer, Chair, Skeptically Examining the Limits of Toxicological Evidence in the

          Courtroom (2013)

     Symposium Organizer, Chair, Implications or Reactive Intermediates, Salt Lake (2010)

     Symposium Organizer, Chair, Metabolic Syndrome and DILI, Salt Lake (2010)

     Symposium Organizer, Chair, Obesity as a Modulator of Chemical Toxicity, San Diego (2006)

     Platform Session Chair, Apoptosis, Philadelphia, PA (2000)

     Platform Session Chair, Oxidative Stress, Miami Beach, FL (1990)

     Platform Session Chair, Glutathione Conjugates and Bioactivation, Seattle, WA (1992)

     Symposium Organizer, Chair, Apoptosis: Molecular Control of Toxicity, New Orleans, LA (1993)

     Poster Discussion Session Chair, Xenobiotic-Induced Apoptosis, Dallas, TX (1994)

     Poster Session Chair, Carcinogenesis, Baltimore, MD (1995)

     Platform Session Chair, Molecular/Cellular, Anaheim, CA  (1996)

        Poster Discussion Chair, Molecular Aspects of Oxidative Stress, Cincinnati, OH (1997)

   Federation of American Societies for Experimental Biology

       Co-Chair, Drug Metabolism and Toxicity II, Las Vegas, NV (1988)

     Platform Session Chair, Toxicology I, Atlanta, GA (1991)

   Continuing Education

   Speaker, Cardiovascular Disease, University of New Mexico (1989)

   Invited Course Lecturer

   Advanced Pathology/Toxicology, Dept Pathology, U Texas Medical Branch, Galveston, TX (1992)

   Advanced Principles Toxicology, Dept Pharmacol/Toxicology, Michigan State U,  (1998)

External Promotion & Tenure Reviews

   40 Reviews for 22 Universities


Awards and Honors

Awards and Honors Recognizing Personal and Research Group Achievement

1967  Freshman Honor Society Awardee, Ithaca College, Ithaca, NY

1968  Dean's List (1967, 1968, 1969), Ithaca College, Ithaca, NY

1970  Graduate Teaching Assistantship, Bucknell University, Lewisburg, PA

1978  ASPET Pre-Doctoral Travel Award Finalist to attend the 7th International Congress on

            Pharmacology, Paris, France

1981  Searle Scholar Nominee, State University of New York at Buffalo, Buffalo, NY

1983  Searle Scholar Nominee, State University of New York at Buffalo, Buffalo, NY

1984  Session Convener and Chair, 1984 Buffalo Pharmaceutics Symposium, Buffalo, NY

1984  Visiting Professor, International Institute for Infant Nutrition, Buffalo, NY

1987  Visiting Professor, International Institute for Infant Nutrition, Buffalo, NY

1988  Supervised Graduate Student Received Student Poster Award, Mountain West Society of  Toxicology, Salt Lake             City, UT

1989  Member, Rho Chi Pharmacy National Honor Society

1990  Supervised Graduate Student Received Poster Award, Molecular Biology Section, Society of Toxicology, Miami               Beach, FL

1990  Supervised Graduate Student Received Poster Award, Mountain West Soc of Toxicology, Tucson AZ

1991  Norwegian Marshall Fund Award Recipient

1991  Visiting Scientist, Department of Environmental Medicine, National Institute of Public Health, OsloNorway

   1991  Elected Secretary/Treasurer, Mountain West Society of Toxicology

   1992  Director and Chair, Society of Toxicology Placement Committee

1992  Fountain of Youth Award, College of Pharmacy Class of 1992          

1993  Certificate of Appreciation, Food and Drug Administration Committee for Advanced Scientific Education,                            Washington, DC

   1993  Elected Treasurer, Mountain West Society of Toxicology

   1993  Marshall, College of Pharmacy Commencement, University of New Mexico

1993  Supervised Graduate Student Received Abstract/Manuscript Award, Mechanisms Specialty Section,

            Society of Toxicology, New Orleans, LA

1993  Supervised Graduate Students (2) Received Outstanding Student Presentation Awards, Southwest

          and Rocky Mountain Division of the American Association for the Advancement of Science, Abq, NM

   1994  Elected Member, Society of Toxicology Education Committee

   1994  Vice President, Section on Toxicology, International Union of Pharmacology

1994  Supervised Graduate Student Received Best Graduate Student Poster, International Society for the

            Study of Xenobiotics, North American Meeting, Tucson, AZ

1994  Biographical Listing: Who's Who in the West

   1995  Inaugural Chair, Society of Toxicology Education Sub-Committee on Minority Programs

1995  Teacher of the Year Award, College of Pharmacy, University of New Mexico, Albuquerque, NM

1995  Nominee, Outstanding Teacher of the Year Award, University of New Mexico, Albuquerque, NM

   1995  Recognized by American Association of Colleges of Pharmacy as 1995 Teacher of the Year at

            Annual Meeting, Philadelphia, PA

1996  Biographical Listing: Five Thousand Personalities of the World

   1996  Member of Executive Committee, Division of Toxicology, American Society for Pharmacology

            and Experimental Therapeutics

   1996  Marshall, College of Pharmacy Commencement

   1996  Elected Vice President-Elect, Mountain West Society of Toxicology

   1996  Elected Councilor, Mechanisms Specialty Section, Society of Toxicology

   1996  Chair, Education Committee, Society of Toxicology

   1996  Biographical Listing: Who's Who in Medicine and Healthcare

   1996  Chairman, Division of Toxicology Executive Committee, American Society for Pharmacology and

             Experimental Therapeutics

1997  Supervised Graduate Student Received Popejoy Outstanding Dissertation Award for the Best Dissertation in                    Life/Physical Sciences and Engineering Between 1994-1997 at the University of New Mexico, Albuquerque, NM

   1998  Member, Volwiler Award Committee of the American Association of Colleges of Pharmacy

   2000  Secretary Elect, Society of Toxicology

   2005  Member, Volwiler Award Committee of the American Association of Colleges of Pharmacy

 2004  Elected Fellow, Academy of Toxicological Sciences    


Recent Publications

RESEARCH PUBLICATIONS 

1. Corcoran GB:  Reactions of a 1-Aza-3-azoniabicyclo[3.1.0]hex-3-ene salt and its derivatives.  Master of Science Thesis, Bucknell University, Lewisburg, PA, 1973.

 2. Corcoran GB:  Mechanism of protection against acetaminophen-induced hepatic necrosis by N-acetylcysteine and other sulfhydryl nucleophiles.  Doctor of Philosophy Dissertation, George Washington University, Washington, DC, 1980.
 
3. Heine HW, Newton TA, Blosick GJ, Irving KC, Meyer C, Corcoran GB:  Aziridines. XXVI. Reactions of 1,3-diazabicyclo-[3,1,0]-hex-3-enes.  J Org Chem 38: 651-654, 1973.  

4. Nelson SD, Mitchell JR, Timbrell JA, Snodgrass WR, Corcoran GB:  Isoniazid and iproniazid: Activation of metabolites to toxic intermediates in man and rat.  Science  193: 901-903, 1976.

 5. Mitchell JR, Corcoran GB:  Macromolecular binding in assessing drug and chemical-induced tissue lesions.  J Environ Pathol Toxicol 1: 101-115, 1977. 

6. Corcoran GB, Mitchell JR, Vaishnav YN, Horning EC, Nelson SD:  Formation of chemically reactive metabolites from drugs.  In: Advances in Pharmacology and Therapeutics: Toxicology, JR Boissier, P Lechat, J Fichelle, eds, Vol 9, Pergamon Press, Oxford, pp 103-111, 1978.

 7. Mitchell JR, Corcoran GB:  Pharmacological and toxic reactions in adult and pediatric medicine.  In: Clinical Pharmacology and Therapeutics: A Pediatric Perspective, BL Mirkin, ed, Year Book Medical Publishers, Inc, Chicago, pp 49-58, 1978. 

8. Mitchell JR, Corcoran GB, Lauterburg BH, Smith CV, Horning EC:  Alkylating and non-alkylating reactive metabolites formed from toxic drugs.  In: The Liver: Quantitative Aspects of Structure and Function, R Preisig, J Bircher, eds, Edito Cantor, Aulendorf, pp 269-279, 1979.

 9. Corcoran GB, Mitchell JR, Vaishnav YN, Horning EC:  Evidence that acetaminophen and N-hydroxy-acetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.  Molec Pharmacol  18: 536-542, 1980. 

10. Mitchell JR, Corcoran GB, Hughes H, Lauterburg BH, Smith CV:  Acute lethal liver injury caused by chemically reactive metabolites.  In: Chemical Indices and Mechanisms of Organ-Directed Toxicity, SS Brown, DS Davies, eds, Pergamon Press, Oxford, pp 117-129, 1981. 

11. Mitchell JR, Corcoran GB, Smith CV, Hughes H, Lauterburg BH, Nelson EB:  Acetaminophen metabolism and toxicity.  In: Drug Reactions and the Liver, M Davis, J Tredger, R Williams, eds, Plenum Press, London, pp 130-143, 1981.

 12. Corcoran GB, Mitchell JR:  Evidence for redox cycling of acetaminophen and its reactive metabolite by endogenous microsomal systems.  In: Biological Reactive Intermediates -II, R Snyder, DV Parke, JJ Kocsis, DJ Jollow, GG Gibson, CM Witmer, eds, Plenum Press, New York, pp 1085-1098, 1982. 

13. Mitchell JR, Corcoran GB, Smith CV, Hughes H, Lauterburg BH:  Alkylation and peroxidation injury from reactive metabolites.  In: Biological Reactive Intermediates - II, R Snyder, DV Parke, JJ Kocsis, DJ Jollow, GG Gibson, CM Witmer, eds, Plenum Press, New York, pp 199-223, 1982. 

14. Lauterburg BH, Corcoran GB, Mitchell JR:  Mechanism of action of N-acetylcysteine in protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest  71: 980-991, 1983.

 15. Mitchell JR, Smith CV, Lauterburg BH, Hughes H, Corcoran GB, Horning EC:  Reactive metabolites and the pathophysiology of acute lethal cell injury.  In: Drug Metabolism and Drug Toxicity, JR Mitchell, MG Horning, eds, Raven Press, New York, pp 301-319, 1984.
 
16. Corcoran GB, Todd EL, Racz WJ, Hughes H, Smith CV, Mitchell JR: Effects of N-acetylcysteine on metabolism and disposition of acetaminophen in mice. J Pharmacol Exp Ther 232: 857-63, 1985.

17. Corcoran GB, Racz WJ, Smith CV, Mitchell JR: Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.  J Pharmacol Exp Ther 232: 864-872, 1985. 

18. Galinsky RE, Corcoran GB:  Influence of advanced age on the formation and elimination of acetaminophen metabolites by male rats.  Pharmacology 32: 313-320, 1986.

 19. Corcoran GB, Wong BK:  Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo:  Studies with N-acetyl-D-cysteine in mice.  J Pharmacol Exp Ther 238: 54-61, 1986. 

20. Wong BK, Galinsky RE, Corcoran GB:  Dissociation of increased sulfation from sulfate replenishment and hepatoprotection in acetaminophen poisoned mice by N-acetylcysteine stereoisomers.  J Pharmaceut Sci 75: 878-880, 1986.  

21. Corcoran GB:  Pharmacokinetic considerations in total parenteral nutrition.  In: Total Parenteral Nutrition: Indications, Utilization, Complications, and Pathophysiological Considerations, E Lebenthal, ed, Raven Press, New York, pp 125-140, 1986. 

22. McLean AJ, Lalka D, Corcoran GB, Melander A:  Drug-nutrient interactions.  In: Recent Advances in Clinical Nutrition: 2, ML Wahlqvist, AS Truswell, eds, John Libby & Sons, London, pp 1-8, 1986.

 23. Wong BK, U S-WE, Corcoran GB:  An overfed rat model that reproduces acetaminophen disposition in obese humans.  Drug Metab Dispos 14: 674-679, 1986. 

24. Wong GB, Chan HC, Corcoran GB:  Selective effects of N-acetylcysteine stereoisomers on hepatic glutathione and plasma sulfate in mice.  Toxicol Appl Pharmacol 86: 421-429, 1986. 

25. Wong BK, Corcoran GB:  Effect of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.  Res Comm Chem Pathol Pharmacol 55: 397-408, 1987.

 26. Corcoran GB, Wong BK, Shum L, Galinsky RE:  Acetaminophen sulfation deficit in obese rats overfed an energy-dense Cafeteria diet.  Endocr Res 13: 101-121, 1987. 

27. Corcoran GB, Wong BK:  Obesity as a risk factor in drug-induced organ injury: Increased liver and kidney damage by acetaminophen in the obese overfed rat. J Pharmacol Exp Ther  241: 921-7, 1987.

 28. Corcoran GB, Chung S-J, Salazar DE:  Early inhibition of plasma membrane sodium ion transport during acetaminophen hepatotoxicity.  Biochem Biophys Res Comm 149: 203-207, 1987. 

29. Corcoran GB, Wong BK, Neese BL:  Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice.  Res Comm Chem Pathol Pharmacol 58: 291-304, 1987.

 30. Galinsky RE, Corcoran GB: Suppression of acetaminophen conjugation and conjugate elimination in rat by metyrapone, a classical cytochrome P-450 inhibitor. Drug Metab Dispos 16: 348-54, 1988. 

31. Corcoran GB, Bauer JA, Lau T-WD: Immediate rise in intracellular calcium and glycogen phosphorylase a activities during acetaminophen covalent binding leading to hepatotoxicity in mice.  Toxicology 50: 157-167, 1988.

 32. Salazar DE, Corcoran GB:  Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass.  Amer J Med 84: 1053-1060, 1988. 

33. Corcoran GB, Salazar DE:  Obesity as a risk factor in drug-induced organ injury II Increased renal cytochrome P-450 in the obese overfed rat.  Drug Metab Dispos 16: 898-900, 1988. 

34. Corcoran GB, Salazar DE, Schentag JJ:  Excessive aminoglycoside nephrotoxicity in obese patients.  Amer J Med 85: 279, 1988.

 35. Salazar DE, Sorge CL, Corcoran GB:  Obesity as a risk factor in drug-induced organ injury. VI. Increased hepatic P450 concentration and microsomal ethanol oxidizing activity in the overfed rat.  Biochem Biophys Res Comm  157: 315-320, 1988. 

36. Matsumoto RM, Jusko WJ, Corcoran GBIn vitro hepatic drug metabolism in an overfed rat model of human obesity.  Drug-Nutr Interact  5: 237-247, 1988.

 37. Corcoran GB, Salazar DE, Chan HH:  Obesity as a risk factor in drug-induced organ injury. III. Increased liver and kidney injury by furosemide in the obese overfed rat.  Toxicol Appl Pharmacol8: 12-24, 1989. 

38. Corcoran GB, Salazar DE, Sorge CL:  Pharmacokinetic characteristics of the obese overfed rat.  Intl J Obesity 13: 69-79, 1989.

 39. Corcoran GB, Salazar DE:  Obesity as a risk factor in drug-induced organ injury IV Increased gentamicin nephrotoxicity in the obese overfed rat.  J Pharmacol Exp Ther 248: 17-22, 1989.
 

40. Corcoran GB, Salazar DE:  Pharmacological considerations in childhood obesity. In: Textbook of Gastroenterology and Nutrition in Early Childhood, E Lebenthal, ed, Raven Press, New York, NY, pp 75-86, 1989. 

41. Wong BK, Corcoran GB:  N-Acetylcysteine stereoisomers as in vivo probes of the role of glutathione in drug detoxification.  In: Handbook of Glutathione: Metabolism and Physiological Functions, J Via, ed, CRC Press, Boca Raton, FL, pp 255-262, 1990.

 42. Ray SD, Sorge CL, Raucy JL, Corcoran GB:  Early loss of genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.  Toxicol Appl Pharmacol 106: 346-351, 1990. 

43. Griener JC, Msall ME, Cooke RE, Corcoran GB: Noninvasive determination of acetaminophen disposition in Down's syndrome.  Clin Pharmacol Ther 48: 520-8, 1990.

 44. Ray SD, Sorge CL Tavacoli, A Raucy, JL, Corcoran GB:  Extensive alteration of genomic DNA and rise in nuclear Ca2+ in vivo after hepatotoxic acetaminophen overdose in mice."  In: Biological Reactive Intermediates IV  Molecular and Cellular Effects and Their Impact on Human Health, DJ Jollow, R Snyder, IG Sipes, eds, Plenum Press, New York, pp 699-705, 1991. 

45. Raucy JL, Lasker JM, Kraner JC, Salazar DE, Lieber CS, Corcoran GB:  Induction of P450IIE1 in the obese overfed rat.  Molec Pharmacol 39: 275-280, 1991.

 46. Shen W, Kamendulis LM, Ray SD, Corcoran GB:  Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death.  Toxicol Appl Pharmacol 111: 242-254, 1991. 

47. Corcoran GB, Ray SD:  Damage to the nucleus and acute cell death produced by alkylating hepatotoxins.  In: Molecular Theories of Cell Life and Death, S Ji, ed, Rutgers University Press, New Brunswick, NJ, pp 384-400, 1991.  

48. Shen W, Kamendulis LM, Ray SD, Corcoran GB:  Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Effects of Ca2+-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death.  Toxicol Appl Pharmacol 112: 32-40, 1992.  http://www.ncbi.nlm.nih.gov/pubmed/1310169 

49. Burchiel SW, Davis DP, Ray SD, Sorge CL, Archuleta M, Thilsted J, Corcoran GB:  DMBA-Induced cytotoxicity in lymphoid and nonlymphoid organs of B6C3F1 mice: relation of cell death to target cell intracellular calcium and DNA damage.  Toxicol Appl Pharmacol  13: 126-132, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1553745  

50. Salazar DE, Corcoran GB:  Obesity as a risk factor in drug-induced organ injury V Increased renal uptake of gentamicin in the obese overfed rat.  Drug Metab Dispos 20: 402-406, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1355715 

51. Corcoran GB, Ray SD:  Contemporary Issues - The role of the nucleus and other compartments in acute cell death produced by alkylating hepatotoxicants.  Toxicol Appl Pharmacol 113: 167-83, 1992.  http://www.ncbi.nlm.nih.gov/pubmed/1561626 

52. Ray SD, Sorge CL, Kamendulis LM, Corcoran GB:  Ca2+-Activated DNA fragmentation and dimethylnitrosamine-induced hepatic necrosis: Effects of Ca2+-endonuclease and poly(ADP-Ribose) polymerase inhibitors in mice.  J Pharmacol Exp Ther  63: 387-394, 1992.  http://jpet.aspetjournals.org/content/263/1/387.long  

53. Kamendulis LM, Corcoran GB:  Independence and additivity of cultured hepatocyte killing by Ca2+ overload and ATP depletion.  Toxicol Lett 63: 277-287, 1992.  http://www.sciencedirect.com/science/article/pii/0378427492900907   

54. Ray SD, Kamendulis LM, Gurule MW, Yorkin RD, Corcoran GB:  Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.  FASEB J 7: 453-463, 1993.  http://www.fasebj.org/cgi/reprint/7/5/453 

55. Kraner JC, Lasker JM, Corcoran GB, Ray SD, Raucy JL:  Induction of P450IIE1 by acetone in isolated rabbit hepatocytes involves increased protein synthesis.  Biochem Pharmacol 45: 1483-1492, 1993.  http://www.ncbi.nlm.nih.gov/pubmed/8471070 

56. Ramzan I, Wong BK, Corcoran GB:  Pain sensitivity in dietary-induced obesity.  Physiol Behav 54: 433-435, 1993.   http://www.sciencedirect.com/science/article/pii/0031938493902314 

57. Salazar DE, Sorge CL, Jordan SW, Corcoran GB:  Obesity decreases hepatic glutathione and increases allyl alcohol-induced periportal necrosis in the obese overfed rat.  Intl J Obesity 18: 25-33, 1994.  http://www.ncbi.nlm.nih.gov/pubmed/8130812 

58. Corcoran GB, Fix LF, Jones DP, Moslen MT, Nicotera P, Oberhammer FA, Buttyan R:  Contemporary Issues.  Apoptosis: Molecular control point in toxicity.  Toxicol Appl Pharmacol 128: 169-181, 1994.  http://www.sciencedirect.com/science/article/pii/S0041008X84711951  

59. Kamendulis LM, Corcoran GB:  DNA as a critical target in toxic cell death: potentiation of dimethylnitrosamine toxicity in cultured mouse hepatocytes by DNA repair inhibitors.  J Pharmacol Exp Ther 271: 1695-1698, 1994.  http://jpet.aspetjournals.org/content/271/3/1695.long 

60. Fischer-Nielsen A, Corcoran GB, Poulsen HE, Kamendulis LM, and Loft S:  Menadione induced DNA fragmentation without 8-hydroxy-2'-deoxyguanosine formation in isolated rat hepatocytes.  Biochem Pharmacol 49: 1469-1474, 1995.  http://www.sciencedirect.com/science/article/pii/000629529400525Q

 61. Kamendulis LM, Shen W, Ray SD, Corcoran GB:  Dimethylnitrosamine-induced cytotoxicity in cultured mouse hepatocytes.  J Toxicol Environ Health  46: 31-46, 1995.

62. Johnston DE, Marcadis D, Corcoran GB, DeBetta M, Salas VM, Ramos HC: Purification of primary human hepatocytes using Ricin A chain.  In Vitro Cell Dev Biol 32: 388-390,1996.  http://link.springer.com/article/10.1007/BF02722998#page-2 

63. Salas VM, Corcoran GB: Ca2+-Dependent DNA damage and cAMP-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.  Hepatology 25: 1432-1438, 1997. http://www3.interscience.wiley.com/cgi-bin/fulltext/106594724/PDFSTART 

64. Bezin L, Anastasiadis PZ, Corcoran GB, Nygaard TG, Levine RA: Tetrahydrobiopterin metabolism in cell death by apoptosis. In: Chemistry and Biology of Pteridines and Folates, H Rokos and W Pfleiderer (Eds), Blackwell Publishers, Berlin, pp 747-754, 1997. 

65. Groc L, Jackson-Hunter T, Jiang H, Bezin L, Koubi D, Corcoran GB, and Levine RA:  Nitric oxide synthase inhibition during development: effect on apoptotic death of dopamine neurons. Dev Brain Res 138: 147-153, 2002.  http://www.sciencedirect.com/science/article/pii/S0165380602004649 

66. Jiang H, Koubi D, Groc L, Hunter T, Anastasisdis P, Rodriguez A, Corcoran GB, Levine R: The role of tetrahydrobiopterin (BH4) in apoptosis of catecholamine (PC12) cells induced by trophic factor withdrawal. In: Chemistry &Biology of Pteridines & Folates, S. Milstien, G. Kapatos, R. Levine and B. Shane (Eds), Kluwer Academic Publishers, Boston/Dordrecht/London, pp 405-408, 2002.

67. Koubi D, Jiang H, Hunter T, Anastasisdis PZ, Rodriguez AI, Corcoran GB, Levine RA. The involvement of tetrahydrobiopterin in ischemia-induced apoptosis. In: Chemistry and Biology of Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds), Kluwer Academic Publishers, Boston-Dordrecht-London, pp. 409-413, 2002.

68. Koubi D, Jiang H, Hunter T, Rodriguez AI, Corcoran GB, Levine RA: Tetrahydrobiopterin (BH4) mediates necrotic death of PC12 cells exposed to ischemia-like conditions. In: Pterins, Folates, and Neurotransmitters in Molecular Medicine, SPS Verlagsgesellscraft mbH, Heilbronn, Germany, pp. 35-40, 2003. 

69. Leslie SW, Corcoran GB, MacKichan JJ, Undie AS, Vanderveen RP, Miller KW. Pharmacy Scholarship Reconsidered: The Report of the 2003-2004 Research and Graduate Affairs Committee. Am J Pharm Educ   68: S6, 2004.http://www.aacp.org/governance/COMMITTEES/reasearchgraduateaffairs/Documents/2003%20

to%202004%20Research%20and%20Graduate%20Affairs%20Committee.pdf 

70. Koubi D, Jiang H, Zhang L, Tang W, Kuoa J, Rodriguez AI, Jackson-Hunter T, Seidman MD, Corcoran GB, Levine RA: Role of the Bcl-2 family of proteins in mediating apoptotic death of PC12 cells exposed to oxygen and glucose deprivation.  Neurochem Intl 46: 73-81, 2005.http://www.sciencedirect.com/science/article/pii/S0197018604001238 

71. Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA.  Resvetratrol-induced apoptotic cell death in human U251 glioma cells. Mol. Cancer Therapeutics 4: 554-561, 2005.  http://mct.aacrjournals.org/content/4/4/554.long 

72. Corcoran GB.  Obesity as an Occult Risk Factor in Drug- and Chemical-Induced Toxicities.  In: “Phytopharmaceuticals for Obesity Treatment: Pathophysiology and Weight Management," Debasis Bagchi and Harry Preuss, eds., CRC Press, Boca Raton, FL, pp 165-173, 2007. 

73. Ray SD, Corcoran GB.  Cell death and apoptosis.  In: "General and Applied Toxicology," B. Ballantyne, T. Marrs and T. Syversen, Eds, Nature Publishers, Vol 1, pp. 247-312, 2009. 

74. Patel N, Joseph C, Corcoran GB, Ray SD.  Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL, and p53 expression while preventing apoptotic and necrotic death in the liver. Toxicol Appl Pharmacol 245: 143-152, 2010.  http://www.sciencedirect.com/science/article/pii/S0041008X10000451 

75. Hirata A, Corcoran GB, Hirata F:  Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.  Toxicol Appl Pharmacol 248: 45-51, 2010.  http://www.sciencedirect.com/science/article/pii/S0041008X10002310 

76. Hirata A, Corcoran GB, Hirata F:  Carcinogenic heavy metals As3+ and Cr6+ increase nuclear mono-ubiquinated annexin A1 affinity for DNA containing 8-oxo-guanosine and promote translesion DNS synthesis Toxicol Appl Pharmacol 252: 159-164, 2011.  http://www.sciencedirect.com/science/article/pii/S0041008X10002310  

77. Ismail S, Tathod J, Parmar M, Corcoran GB, Ray SD:  Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury.  Molec Cell Biochem 365: 351-61, 2012  http://link.springer.com/article/10.1007%2Fs11010-012-1277-z  

78. Corcoran GB.  The obese and overweight: A new sensitive population for drug and chemical toxicities ?.  In: "Obesity: Epidemiology, Pathophysiology and Prevention," Debasis Bagchi and Harry Preuss, eds., 2nd Edition, CRC Press, Boca Raton, FL, pp 263-274, 2012. 

79. Hirata F, Corcoran GB, Hirata A: “Mono-Ubiquitination of Nuclear Annexin A1 and Mutagenesis,” In: Mutagenesis, Rajnikant Mishra, Editor, Intech, 2012.  http://dx.doi.org/10.5772/50800  

80. S. Betharia, F. F. Farris, G. B. Corcoran and S. D. Ray. ‘Mechanisms of Toxicity’ In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 165-175, 2014.  http://www.sciencedirect.com/science/article/pii/B9780123864543003298 

81. Corcoran GB, and Ray SD. ‘Benzyl Alcohol’ In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 429-432, 2014 http://www.sciencedirect.com/science/article/pii/B9780123864543002517 

82. Hirata A, Harada T, Corcoran GB, Hirata F: Inhibitory effects of flavonoids on nuclear mono-ubiquitinated annexin A1 helicase activity and mutation of the thymidine kinase gene in L5178 th(+/-) cells.  Mutat Res Fundam Mol Mech Mutagen 759: 29-36, 2014.http://www.ncbi.nlm.nih.gov/pubmed/?term=Hirata+A%2C+Harada+T%2C+Corcoran+GB%2C+Hirata+F%3A+Inhibitory+effects+of+flavonoids

 


Primary Research Interest

Research interests are multidisciplinary and translational.  They focus on cellular injury and cell death, as well as factors governing drug and chemical-induced injuries, including drug metabolism and nutrition.  Approaches designed to translate basic discoveries to improve human health involve integrated in vivo models, cellular and molecular biology, pharmacokinetics, synthetic chemistry, and retrospective and prospective clinical investigation of human volunteers and patients.  Specific areas of investigation include cell death by necrosis and apoptosis, the role of DNA damage in acute cell death, drug and chemical injury to the liver, role of nutrition and obesity in drug and chemical injury, drug biotransformation including by CYPs, and particularly the toxicity of acetaminophen (paracetamol).


Personal Interests

Member, Knox United Presbyterian Church Sanctuary Choir (1981-88)

Volunteer, The American Cancer Society (1983-88)

President, Knox United Presbyterian Church Sanctuary Choir (1985-88)

Member, The Knox Choraliers (outreach vocal group ministering to the disadvantaged) (1981-88)

Member, Treasury Committee, The Knox Choraliers (1985-88)

Spokesperson, Concerned Citizens of Kenmore (1983-85)

Block Captain, Neighborhood Watch Group (1983-88)

Mock Trial Participant, University of New Mexico School of Law (1993)

Assistant Coach and Volunteer, Albuquerque Youth Soccer Organization (1994-96)

Volunteer, Boy Scouts of America, New Mexico Council (1993-96)

Pro Bono Toxicology Consultation, State of New Mexico Public Defenders Offices (1991-96)

Assistant Coach and Volunteer, Albuquerque Youth Basketball League (1994-96)

Volunteer, Boy Scouts of America, Detroit Area Council (1997-1999)

Assistant Den Leader, Boy Scouts of America, Detroit Area Council (1999-2002)

   Deacon, First Presbyterian Church, Northville, MI (2000-2003)

   Outreach Committee, First Presbyterian Church, Northville, MI (2000-)

   Volunteer, Habitat for Humanity (2000-)

   Volunteer, Gleaners Community Food Bank (1999-)

   Volunteer, Fort Street Presbyterian Church Open Door Mission (1999-)

   Regional Organizer, Crop Walk, Church World Services (2000-)

   Elder, First Presbyterian Church, Northville, MI (2003-2006)

   Member of Session, First Presbyterian Church, Northville, MI (2003-2006)

   Moderator, Nominating Committee, First Presbyterian Church, Northville, MI (2003-2006)

   Coach, Quad Cities Baseball League (2003-4)

   Personnel Search Committee, Member, First Presbyterian Church, Northville, MI (2003-2004)

   Moderator, Mission & Outreach Committee, First Presbyterian Church, Northville, MI (2004-2006)

   Founding Member, Centers for Intentional Community, Detroit, MI (2004-)


Responsibilities

EDITORIAL BOARDS AND REFEREEING 

     Editorial Boards

         Toxicology and Applied Pharmacology Toxicology and Applied Pharmacology

            (Associate Editor 2002-Date, Member 1993-1996)

        Journal of Pharmaceutical Sciences and Pharmacology (Editor, 2014-Date)

        MO Journal Toxicology (Editor, 2014-Date)

        Basic and Clinical Pharmacology and Toxicology (Member, 2002-2012)

        Pharmacology and Toxicology (Member, 1993-2002)
 
        Toxicology Letters (Member, 1993-1997)

        Journal of Toxicology and Environmental Health (Member, 1992-1998)

     Ad Hoc Journal and Monograph Review

        American Journal of Pathology

        American Journal of Physiology

        Alcoholism: Clinical and Experimental Research

        Archives of Biochemistry and Biophysics                        

        Biochemical Pharmacology

        Biopharmaceutics and Drug Disposition

        Blood

        Canadian Journal of Physiology and Pharmacology

        Cellular and Molecular Biology

        Chemical Research in Toxicology

        Chemico-Biological Interactions

        Clinical Pharmacology and Therapeutics

        CRC Monographs

        DICP, The Annals of Pharmacotherapy

        Drug Metabolism and Disposition

        Experimental Cell Research

        Fundamental and Applied Toxicology

        Gastroenterology

        Hepatology

        International Journal of Obesity

        International Journal of Pharmaceutics

        Journal of Basic and Clinical Pharmacology

        Journal of Clinical Investigation

        Journal of Histochemistry and Cytochemistry

        Journal of Medicinal Chemistry

        Journal of Pediatric Gastroenterology and Nutrition                     

        Journal of Pharmaceutical Sciences

        Journal of Pharmacology and Experimental Therapeutics          

        Journal of Toxicology and Environmental Health

        Life Sciences

     Molecular Pharmacology

        Pharmacology and Toxicology

        Research Communications in Chemical Pathology and Pharmacology

        Toxicological Sciences

        Toxicology

        Toxicology and Applied Pharmacology

        Toxicology In Vitro

        Toxicology Letters


PUBLIC ADVISORY GROUPS 

       US Environmental Protection Agency Scientific Advisory Board - Exposure and Human Health

             Committee (Member 2003-09)

       US Environmental Protection Agency Federal Insecticide, Fungicide and Rodenticide Act

             Scientific Advisory Panels (Member 2003-09

       US Environmental Protection Agency Federal Insecticide, Fungicide and Rodenticide Act N- 

            Methyl-Carbamates Scientific Advisory Panel (Member 2004-06)

       US Environmental Protection Agency Scientific Advisory Board Perfluorooctanoic Acids 

             Scientific Advisory Panel (Member 2004-06)

       US Environmental Protection Agency Scientific Advisory Board PPAR-alpha Scientific Advisory

             Panel (Member 2003-06)

       The National Academies Vietnam Education Foundation Fellowships Panel (Member 2003-05

       The National Academies National Research Council Hughes Pre-Doctoral Fellowships 

             Neurology and Physiology 1 Panel, (Chairman 2002-2003, Member 2000-03)

        Texas Higher Education Coordinating Board External Review Consultant for Texas Southern        University MS and PhD in Pharmaceutical Sciences - 2004

        Center for Research on Environmental Disease, University of Texas Austin and MD Anderson      Cancer Center, Pilot Programs - External Reviewer 2004

        Biochemical Sciences (BCS-IRG) Special Emphasis Panel Study Section - Member 2000

        Veterans Administration Merit Review Committee, Office of External Review - Ad Hoc Member              2000

        Hans W. Vahlteich Endowed Research Program, University of Illinois - Reviewer 1999

        Alcohol/Toxicology-1 Study Section, National Institutes of Health - Member 1996-2002

        Multidisciplinary Special Emphasis Panel, National Institutes of Health - Member 1997

        University of Puerto Rico MBRS Program Review - Ad Hoc Reviewer 1997

        Multidisciplinary Special Emphasis Panel, National Institutes of Health - Chair 1997

        Veterans Administration, Eastern Research & Development Office - Ad Hoc Reviewer 1992-96

        Veterans Administration, National Research and Development Office - Ad Hoc Reviewer 1999-              Date

        Medical Research Council of Canada – Ad Hoc Reviewer 1984-Date

        Foundation for Advancement of Science Technology – Ad Hoc Reviewer 1985-1990

        Henry Ford Hospital Research Administration – External Reviewer 1986-1990

        University of California Coordinating Committee on Graduate Affairs – External Reviewer 1985

        American Cancer Society University of New Mexico Research Starter Grants 1992-4; 1994-96

        Internal Advisory Board, Epidemiology and Toxicology of Lung Disease Training Grant, UNM                 1996