Wayne State University

Aim Higher

Faculty Biography
 

George B. Corcoran PhD


(313) 577-1737

corcoran@wayne.edu
EACPHS Room 3615

Appointments

Chair and Professor, Department of Pharmaceutical Sciences



Education Training

1966  Diploma                            Longmeadow High School, Longmeadow, MA

1970  BA  Chemistry                 Department of Chemistry, Ithaca College, Ithaca, NY

1973  MS  Chemistry                 Department of Chemistry, Bucknell University, Lewisburg, PA

1980  PhD  Pharmacology        Department of Pharmacology, School of Medicine, George

          (Minor In Biochemistry)           Washington University, Washington, DC

1981  Postdoctoral Fellow        Pharmacology/Toxicology Program, Department of Medicine,

          In Pharmacology /              Baylor College of Medicine, Houston, TX

              Toxicology  


Positions and Employment

CURRENT  PROFESSIONAL  POSITIONS,  TITLES,  AFFILIATIONS

1996    Professor & Chairman, Dept of Pharmaceutical Sciences, Eugene Applebaum College of

            Pharmacy & Health Sciences, Wayne State University, Detroit, MI  (Tenure awarded in 1996)

1999    Adjunct Professor, Department of Pediatrics, School of Medicine, Wayne State Univ, Detroit, MI

2004    Member, Academy of Toxicological Sciences Member

2013    Member, WSU Michigan Translational Research and Commercialization Oversight Committee

2012    Member, Executive Board, Academy of Toxicological Sciences

2012    Member, National Toxicology Program Board of Scientific Counselors

2011    Member, Advisory Board, WSU Nano Incubator Program

2011    Member, Executive Board, Association of Medical School Pharmacology Chairs

2004    Visiting Professor, Addis Ababa School of Medicine, Addis Ababa, Ethiopia

2002    Associate Editor, Toxicology and Applied Pharmacology

1997    Member, Graduate Faculty, Wayne State University, Detroit, MI

2009    Member, Advisory Board, Institute for Environmental Health Sciences, Wayne State U

1996    Member, Institute for Environmental Health Sciences, Wayne State University

 1996    Member, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 

 
PREVIOUS  POSITIONS,  TITLES,  AFFILIATIONS

2012-13     Past Chair, Executive Board, Council of Scientific Society Presidents

2007-13     Member, Executive Board, Council on Scientific Societies Presidents

2007-13     Member, WSU Clinical Translational Science Award (CTSA) Steering Committee (MACTS)

2007-13     Director, WSU CTSA Novel Clinical and Translational Methodologies

2002-12     Member, Editorial Board, Basic and Clinical Pharmacology and Toxicology

2008-11     Member, Scientific Advisory Committee on Alternative Toxicological Methods (SACATM)

2008-09     Past President, Society of Toxicology

2007-08     President, Society of Toxicology

2006-07     Vice President, Society of Toxicology

2005-06     Vice President-Elect, Society of Toxicology

2004-10     Councilor, International Union of Toxicology

2003-09     Member, US Environmental Protection Agency Scientific Advisory Board - EHHC

2003-09     Member, US Environmental Protection Agency FIFRA Scientific Advisory Panels

2004-06     Member, US EPA FIFRA N-Methyl-Carbamates Scientific Advisory Panel

2004-06     Member, US EPA SAB Perfluorooctanoic Acids Scientific Advisory Panel

2003-06     Member, US EPA SAB PPAR-alpha Scientific Advisory Panel

2003-05     Member, Vietnam Education Foundation Fellowships Panel, The National Academies

2002-03     Chairman, National Research Council Hughes Pre-Doctoral Fellowships Neurology & Physiology

                  1 Panel, The National Academies (Member 2000-03)

2001-03     Secretary, Society of Toxicology

1999-04     Member, Steering Committee, John D. Dingell VA Diabetes Research Enhancement Award

                  Program, Detroit, MI

1998-06     Member, Advisory Board, Children’s Center for Clinical Pharmacology, Children’s Hospital of MI

1996-02     Member, Alcohol Toxicology-1 Study Section, National Institutes of Health, Bethesda, MD

1996-02     Member, Program Leaders Group, Karmanos Cancer Institute, Wayne State U, Detroit, MI

2000-01     Secretary-Elect, Society of Toxicology

1999-07     Member, John D. Dingell VA Research & Development Committee

1997-99     Member, Scientific Council, American Society for Pharmacology and Experimental Therapeutics

1996-98     Chairman, Division of Toxicology Executive Committee, American Society for Pharmacology and

                  Experimental Therapeutics

1997-99     Member, Human Genetics Program Advisory Group, Wayne State University

1996-08     Member, National Institute of Environmental Health Sciences Center for Molecular & Cellular

                  Toxicology with Human Applications, Wayne State University, Detroit, MI

1993-97     Member, Editorial Board, Toxicology Letters

1993-96     Member, Editorial Board, Toxicology and Applied Pharmacology

1993-97     Professor of Pharmacology & Toxicology, Basic Pharmaceutical Sciences, University of New

                  Mexico College Pharmacy, Albuquerque, NM

1992-98     Member, Editorial Board, Journal of Toxicology and Environmental Health

1989-96     Chairman, Toxicology Graduate Program, University of New Mexico College of Pharmacy,

                  Albuquerque, NM

1993-96     Adjunct Professor, Dept of Biochemistry, U New Mexico School of Medicine, Albuquerque, NM

1992-96     Faculty Affiliate, Center on Alcoholism, Substance Abuse, and Addictions, University of New

                  Mexico, Albuquerque, NM

1990-93     Adjunct Associate Professor, Department of Biochemistry, University of New Mexico School of

                  Medicine, Albuquerque, NM

1988-93     Associate Professor of Pharmacology and Toxicology, Basic Pharmaceutical Sciences,

                  University of New Mexico College Pharmacy, Albuquerque, NM (Tenure awarded in 1989)

1981-88     Assistant Professor, Dept Pharmaceutics, School of Pharmacy, SUNY at Buffalo, Buffalo, NY

1980-81     Senior Research Scientist, The Methodist Hospital, Texas Medical Center, Houston, TX

1977-80     Research Assistant, Department of Medicine, Baylor College of Medicine, Houston, TX

1974-77     Chemist (Federal Civil Servant), National Heart and Lung Institute, NIH, Bethesda, MD

1972-74     Guest Worker, National Heart and Lung Institute, NIH, Bethesda, MD

1970          Visiting Chemist, Sun Oil Company, Marcus Hook, PA

1970-72     Graduate Teaching Assistant, Department of Chemistry, Bucknell University, Lewisburg PA


Other Experience Professional Memberships

Memberships, Fellowships, and Offices Held in Professional Organizations

1966  Zeta Sigma Nu Honor Society

1968  American Chemical Society (Student Affiliate - Currently Inactive)

1982  American Association for the Advancement of Science (Currently Inactive)

1984  Pharmacy School Pharmacologists (Currently Inactive)

1986  American Association of Pharmaceutical Scientists (Charter Member)

1987  American Society for Pharmacology and Experimental Therapeutics

            Scientific Council: Member (1997-9)

            Division of Drug Metabolism: Member (1988-)

            Division of Toxicology: Member (1991-)

            Division of Toxicology Executive Committee: Chair (1997-9), Member (1996-00)

  1988  Society of Toxicology

           Board of Directors (Council), Chair (2007-2008), Member (2001-2004; 2005-2009)

        Congressional Subcommittee, Chair (2008-2013), Member (2007-date)

        Nominating Committee, Chair (2009), Member (2013-14)

        Undergraduate Education Strategic Work Group, Member (2012-Date)

        Endowment Fund Board, Member (2007-2010)

        Finance Committee, Member (2006-2009)

        Board of Publications, Member (2006-2009); Marketing Subcommittee (2006-2009)

        Membership Services Strategy Committee, Council Liaison (2006-2007)

        Nominating Committee, Council Liaison (2005-2006)

        Program Committee, Chair (2006-2007), Co-Chairman (2005-2006)

        Post-Doctoral Fellow Task Force, Council Liaison (2005-2006)

        Placement Committee, Chair (1992-193); Member (1990-1993); Volunteer (1989-1990)

        Education Committee, Chair (1995-1996); Member (1993-1996)

            Sub-Committee on Community Outreach, Member (1996-1998)  

            Subcommittee on Minority Education Initiatives, Inaugural Chair (1995-1996)

        Mechanisms Specialty Section Elected Councilor (1996-1998), Member (1988-Date)

        Regulatory and Safety Evaluation Specialty Section Member (1993-Date)

1988  Mountain West Chapter of the Society of Toxicology

            Vice President Elect (1996-7); Treasurer (1993-4); Secretary/Treasurer (1991-3); Local

            Organizing Comm Chairperson (1989); Awards Committee (1990, 1994); Member (1988-97)

  1997  Michigan Chapter of the Society of Toxicology Member (1997-)

1988  American Association of Colleges of Pharmacy (1992-), Volwiler Award Committee Member (1997-8)

1993  International Union of Pharmacology

            Section on Toxicology, Vice President  (1994-1998), President (1998-02)

  1999  Michigan Pharmacists Association Member (1999-Date)

  2004  International Union of Toxicology

            Candidate, Secretary-General (2004, 2007)

 

            Councilor (2005-2008, 2008-2011)

OTHER SERVICE TO THE PROFESSION (Also See Present and Past Affiliations)

Society of Toxicology

     Symposium Organizer, Chair, Skeptically Re-Examining the Limits of Toxicology Evidence in the

 

          Courtroom (2014)

          Symposium Organizer, Chair, SOT as a Resource for Congress on Emerging Issues: The Congressional

          Subcommittee Presents a Socratic Debate on Hydraulic Fracturing (2014)

     Roundtable Organizer, Chair, Skeptically Examining the Limits of Toxicological Evidence in the

          Courtroom (2013)

     Symposium Organizer, Chair, Implications or Reactive Intermediates, Salt Lake (2010)

     Symposium Organizer, Chair, Metabolic Syndrome and DILI, Salt Lake (2010)

     Symposium Organizer, Chair, Obesity as a Modulator of Chemical Toxicity, San Diego (2006)

     Platform Session Chair, Apoptosis, Philadelphia, PA (2000)

     Platform Session Chair, Oxidative Stress, Miami Beach, FL (1990)

     Platform Session Chair, Glutathione Conjugates and Bioactivation, Seattle, WA (1992)

     Symposium Organizer, Chair, Apoptosis: Molecular Control of Toxicity, New Orleans, LA (1993)

     Poster Discussion Session Chair, Xenobiotic-Induced Apoptosis, Dallas, TX (1994)

     Poster Session Chair, Carcinogenesis, Baltimore, MD (1995)

     Platform Session Chair, Molecular/Cellular, Anaheim, CA  (1996)

        Poster Discussion Chair, Molecular Aspects of Oxidative Stress, Cincinnati, OH (1997)

   Federation of American Societies for Experimental Biology

       Co-Chair, Drug Metabolism and Toxicity II, Las Vegas, NV (1988)

     Platform Session Chair, Toxicology I, Atlanta, GA (1991)

   Continuing Education

   Speaker, Cardiovascular Disease, University of New Mexico (1989)

   Invited Course Lecturer

   Advanced Pathology/Toxicology, Dept Pathology, U Texas Medical Branch, Galveston, TX (1992)

   Advanced Principles Toxicology, Dept Pharmacol/Toxicology, Michigan State U,  (1998)

External Promotion & Tenure Reviews

   40 Reviews for 22 Universities


Awards and Honors

Awards and Honors Recognizing Personal and Research Group Achievement

1967  Freshman Honor Society Awardee, Ithaca College, Ithaca, NY

1968  Dean's List (1967, 1968, 1969), Ithaca College, Ithaca, NY

1970  Graduate Teaching Assistantship, Bucknell University, Lewisburg, PA

1978  ASPET Pre-Doctoral Travel Award Finalist to attend the 7th International Congress on

            Pharmacology, Paris, France

1981  Searle Scholar Nominee, State University of New York at Buffalo, Buffalo, NY

1983  Searle Scholar Nominee, State University of New York at Buffalo, Buffalo, NY

1984  Session Convener and Chair, 1984 Buffalo Pharmaceutics Symposium, Buffalo, NY

1984  Visiting Professor, International Institute for Infant Nutrition, Buffalo, NY

1987  Visiting Professor, International Institute for Infant Nutrition, Buffalo, NY

1988  Supervised Graduate Student Received Student Poster Award, Mountain West Society of

          Toxicology, Salt Lake City, UT

1989  Member, Rho Chi Pharmacy National Honor Society

1990  Supervised Graduate Student Received Poster Award, Molecular Biology Section, Society of

          Toxicology, Miami Beach, FL

1990  Supervised Graduate Student Received Poster Award, Mountain West Soc of Toxicology, Tucson

          AZ

1991  Norwegian Marshall Fund Award Recipient

1991  Visiting Scientist, Department of Environmental Medicine, National Institute of Public Health, Oslo,

            Norway

   1991  Elected Secretary/Treasurer, Mountain West Society of Toxicology

   1992  Director and Chair, Society of Toxicology Placement Committee

1992  Fountain of Youth Award, College of Pharmacy Class of 1992          

1993  Certificate of Appreciation, Food and Drug Administration Committee for Advanced Scientific

          Education, Washington, DC

   1993  Elected Treasurer, Mountain West Society of Toxicology

   1993  Marshall, College of Pharmacy Commencement, University of New Mexico

1993  Supervised Graduate Student Received Abstract/Manuscript Award, Mechanisms Specialty Section,

            Society of Toxicology, New Orleans, LA

1993  Supervised Graduate Students (2) Received Outstanding Student Presentation Awards, Southwest

          and Rocky Mountain Division of the American Association for the Advancement of Science, Abq, NM

   1994  Elected Member, Society of Toxicology Education Committee

   1994  Vice President, Section on Toxicology, International Union of Pharmacology

1994  Supervised Graduate Student Received Best Graduate Student Poster, International Society for the

            Study of Xenobiotics, North American Meeting, Tucson, AZ

1994  Biographical Listing: Who's Who in the West

   1995  Inaugural Chair, Society of Toxicology Education Sub-Committee on Minority Programs

1995  Teacher of the Year Award, College of Pharmacy, University of New Mexico, Albuquerque, NM

1995  Nominee, Outstanding Teacher of the Year Award, University of New Mexico, Albuquerque, NM

   1995  Recognized by American Association of Colleges of Pharmacy as 1995 Teacher of the Year at

            Annual Meeting, Philadelphia, PA

1996  Biographical Listing: Five Thousand Personalities of the World

   1996  Member of Executive Committee, Division of Toxicology, American Society for Pharmacology

            and Experimental Therapeutics

   1996  Marshall, College of Pharmacy Commencement

   1996  Elected Vice President-Elect, Mountain West Society of Toxicology

   1996  Elected Councilor, Mechanisms Specialty Section, Society of Toxicology

   1996  Chair, Education Committee, Society of Toxicology

   1996  Biographical Listing: Who's Who in Medicine and Healthcare

   1996  Chairman, Division of Toxicology Executive Committee, American Society for Pharmacology and

            Experimental Therapeutics

1997  Supervised Graduate Student Received Popejoy Outstanding Dissertation Award for the Best

          Dissertation in Life/Physical Sciences and Engineering Between 1994-1997 at the University of New

          Mexico, Albuquerque, NM

   1998  Member, Volwiler Award Committee of the American Association of Colleges of Pharmacy

   2000  Secretary Elect, Society of Toxicology

   2005  Member, Volwiler Award Committee of the American Association of Colleges of Pharmacy

 

   2004  Elected Fellow, Academy of Toxicological Sciences    


Recent Publications

RESEARCH PUBLICATIONS 

1. Corcoran GB:  Reactions of a 1-Aza-3-azoniabicyclo[3.1.0]hex-3-ene salt and its derivatives.  Master of Science Thesis, Bucknell University, Lewisburg, PA, 1973.

 

2. Corcoran GB:  Mechanism of protection against acetaminophen-induced hepatic necrosis by N-acetylcysteine and other sulfhydryl nucleophiles.  Doctor of Philosophy Dissertation, George Washington University, Washington, DC, 1980.

 

3. Heine HW, Newton TA, Blosick GJ, Irving KC, Meyer C, Corcoran GB:  Aziridines. XXVI. Reactions of 1,3-diazabicyclo-[3,1,0]-hex-3-enes.  J Org Chem 38: 651-654, 1973. 

 

4. Nelson SD, Mitchell JR, Timbrell JA, Snodgrass WR, Corcoran GB:  Isoniazid and iproniazid: Activation of metabolites to toxic intermediates in man and rat.  Science  193: 901-903, 1976.

 

5. Mitchell JR, Corcoran GB:  Macromolecular binding in assessing drug and chemical-induced tissue lesions.  J Environ Pathol Toxicol 1: 101-115, 1977.

 

6. Corcoran GB, Mitchell JR, Vaishnav YN, Horning EC, Nelson SD:  Formation of chemically reactive metabolites from drugs.  In: Advances in Pharmacology and Therapeutics: Toxicology, JR Boissier, P Lechat, J Fichelle, eds, Vol 9, Pergamon Press, Oxford, pp 103-111, 1978.

 

7. Mitchell JR, Corcoran GB:  Pharmacological and toxic reactions in adult and pediatric medicine.  In: Clinical Pharmacology and Therapeutics: A Pediatric Perspective, BL Mirkin, ed, Year Book Medical Publishers, Inc, Chicago, pp 49-58, 1978.

 

8. Mitchell JR, Corcoran GB, Lauterburg BH, Smith CV, Horning EC:  Alkylating and non-alkylating reactive metabolites formed from toxic drugs.  In: The Liver: Quantitative Aspects of Structure and Function, R Preisig, J Bircher, eds, Edito Cantor, Aulendorf, pp 269-279, 1979.

 

9. Corcoran GB, Mitchell JR, Vaishnav YN, Horning EC:  Evidence that acetaminophen and N-hydroxy-acetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.  Molec Pharmacol  18: 536-542, 1980.

 

10. Mitchell JR, Corcoran GB, Hughes H, Lauterburg BH, Smith CV:  Acute lethal liver injury caused by chemically reactive metabolites.  In: Chemical Indices and Mechanisms of Organ-Directed Toxicity, SS Brown, DS Davies, eds, Pergamon Press, Oxford, pp 117-129, 1981.

 

11. Mitchell JR, Corcoran GB, Smith CV, Hughes H, Lauterburg BH, Nelson EB:  Acetaminophen metabolism and toxicity.  In: Drug Reactions and the Liver, M Davis, J Tredger, R Williams, eds, Plenum Press, London, pp 130-143, 1981.

 

12. Corcoran GB, Mitchell JR:  Evidence for redox cycling of acetaminophen and its reactive metabolite by endogenous microsomal systems.  In: Biological Reactive Intermediates -II, R Snyder, DV Parke, JJ Kocsis, DJ Jollow, GG Gibson, CM Witmer, eds, Plenum Press, New York, pp 1085-1098, 1982.

 

13. Mitchell JR, Corcoran GB, Smith CV, Hughes H, Lauterburg BH:  Alkylation and peroxidation injury from reactive metabolites.  In: Biological Reactive Intermediates - II, R Snyder, DV Parke, JJ Kocsis, DJ Jollow, GG Gibson, CM Witmer, eds, Plenum Press, New York, pp 199-223, 1982.

 

14. Lauterburg BH, Corcoran GB, Mitchell JR:  Mechanism of action of N-acetylcysteine in protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest  71: 980-991, 1983.

 

15. Mitchell JR, Smith CV, Lauterburg BH, Hughes H, Corcoran GB, Horning EC:  Reactive metabolites and the pathophysiology of acute lethal cell injury.  In: Drug Metabolism and Drug Toxicity, JR Mitchell, MG Horning, eds, Raven Press, New York, pp 301-319, 1984.

 

16. Corcoran GB, Todd EL, Racz WJ, Hughes H, Smith CV, Mitchell JR: Effects of N-acetylcysteine on metabolism and disposition of acetaminophen in mice. J Pharmacol Exp Ther 232: 857-63, 1985.

 

17. Corcoran GB, Racz WJ, Smith CV, Mitchell JR: Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.  J Pharmacol Exp Ther 232: 864-872, 1985.

 

18. Galinsky RE, Corcoran GB:  Influence of advanced age on the formation and elimination of acetaminophen metabolites by male rats.  Pharmacology 32: 313-320, 1986.

 

19. Corcoran GB, Wong BK:  Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo:  Studies with N-acetyl-D-cysteine in mice.  J Pharmacol Exp Ther 238: 54-61, 1986.

 

20. Wong BK, Galinsky RE, Corcoran GB:  Dissociation of increased sulfation from sulfate replenishment and hepatoprotection in acetaminophen poisoned mice by N-acetylcysteine stereoisomers.  J Pharmaceut Sci 75: 878-880, 1986.

 

21. Corcoran GB:  Pharmacokinetic considerations in total parenteral nutrition.  In: Total Parenteral Nutrition: Indications, Utilization, Complications, and Pathophysiological Considerations, E Lebenthal, ed, Raven Press, New York, pp 125-140, 1986.

 

22. McLean AJ, Lalka D, Corcoran GB, Melander A:  Drug-nutrient interactions.  In: Recent Advances in Clinical Nutrition: 2, ML Wahlqvist, AS Truswell, eds, John Libby & Sons, London, pp 1-8, 1986.

 

23. Wong BK, U S-WE, Corcoran GB:  An overfed rat model that reproduces acetaminophen disposition in obese humans.  Drug Metab Dispos 14: 674-679, 1986.

 

24. Wong GB, Chan HC, Corcoran GB:  Selective effects of N-acetylcysteine stereoisomers on hepatic glutathione and plasma sulfate in mice.  Toxicol Appl Pharmacol 86: 421-429, 1986.

 

25. Wong BK, Corcoran GB:  Effect of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.  Res Comm Chem Pathol Pharmacol 55: 397-408, 1987.

 

26. Corcoran GB, Wong BK, Shum L, Galinsky RE:  Acetaminophen sulfation deficit in obese rats overfed an energy-dense Cafeteria diet.  Endocr Res 13: 101-121, 1987.

 

27. Corcoran GB, Wong BK:  Obesity as a risk factor in drug-induced organ injury: Increased liver and kidney damage by acetaminophen in the obese overfed rat. J Pharmacol Exp Ther  241: 921-7, 1987.

 

28. Corcoran GB, Chung S-J, Salazar DE:  Early inhibition of plasma membrane sodium ion transport during acetaminophen hepatotoxicity.  Biochem Biophys Res Comm 149: 203-207, 1987.

 

29. Corcoran GB, Wong BK, Neese BL:  Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice.  Res Comm Chem Pathol Pharmacol 58: 291-304, 1987.

 

30. Galinsky RE, Corcoran GB: Suppression of acetaminophen conjugation and conjugate elimination in rat by metyrapone, a classical cytochrome P-450 inhibitor. Drug Metab Dispos 16: 348-54, 1988.

 

31. Corcoran GB, Bauer JA, Lau T-WD: Immediate rise in intracellular calcium and glycogen phosphorylase a activities during acetaminophen covalent binding leading to hepatotoxicity in mice.  Toxicology 50: 157-167, 1988.

 

32. Salazar DE, Corcoran GB:  Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass.  Amer J Med 84: 1053-1060, 1988.

 

33. Corcoran GB, Salazar DE:  Obesity as a risk factor in drug-induced organ injury II Increased renal cytochrome P-450 in the obese overfed rat.  Drug Metab Dispos 16: 898-900, 1988.

 

34. Corcoran GB, Salazar DE, Schentag JJ:  Excessive aminoglycoside nephrotoxicity in obese patients.  Amer J Med 85: 279, 1988.

 

35. Salazar DE, Sorge CL, Corcoran GB:  Obesity as a risk factor in drug-induced organ injury. VI. Increased hepatic P450 concentration and microsomal ethanol oxidizing activity in the overfed rat.  Biochem Biophys Res Comm  157: 315-320, 1988.

 

36. Matsumoto RM, Jusko WJ, Corcoran GBIn vitro hepatic drug metabolism in an overfed rat model of human obesity.  Drug-Nutr Interact  5: 237-247, 1988.

 

37. Corcoran GB, Salazar DE, Chan HH:  Obesity as a risk factor in drug-induced organ injury. III. Increased liver and kidney injury by furosemide in the obese overfed rat.  Toxicol Appl Pharmacol 98: 12-24, 1989.

 

38. Corcoran GB, Salazar DE, Sorge CL:  Pharmacokinetic characteristics of the obese overfed rat.  Intl J Obesity 13: 69-79, 1989.

 

39. Corcoran GB, Salazar DE:  Obesity as a risk factor in drug-induced organ injury IV Increased gentamicin nephrotoxicity in the obese overfed rat.  J Pharmacol Exp Ther 248: 17-22, 1989.

 

40. Corcoran GB, Salazar DE:  Pharmacological considerations in childhood obesity. In: Textbook of Gastroenterology and Nutrition in Early Childhood, E Lebenthal, ed, Raven Press, New York, NY, pp 75-86, 1989.

 

41. Wong BK, Corcoran GB:  N-Acetylcysteine stereoisomers as in vivo probes of the role of glutathione in drug detoxification.  In: Handbook of Glutathione: Metabolism and Physiological Functions, J Via, ed, CRC Press, Boca Raton, FL, pp 255-262, 1990.

 

42. Ray SD, Sorge CL, Raucy JL, Corcoran GB:  Early loss of genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.  Toxicol Appl Pharmacol 106: 346-351, 1990.

 

43. Griener JC, Msall ME, Cooke RE, Corcoran GB: Noninvasive determination of acetaminophen disposition in Down's syndrome.  Clin Pharmacol Ther 48: 520-8, 1990.

 

44. Ray SD, Sorge CL Tavacoli, A Raucy, JL, Corcoran GB:  Extensive alteration of genomic DNA and rise in nuclear Ca2+ in vivo after hepatotoxic acetaminophen overdose in mice."  In: Biological Reactive Intermediates IV  Molecular and Cellular Effects and Their Impact on Human Health, DJ Jollow, R Snyder, IG Sipes, eds, Plenum Press, New York, pp 699-705, 1991.

 

45. Raucy JL, Lasker JM, Kraner JC, Salazar DE, Lieber CS, Corcoran GB:  Induction of P450IIE1 in the obese overfed rat.  Molec Pharmacol 39: 275-280, 1991.

 

46. Shen W, Kamendulis LM, Ray SD, Corcoran GB:  Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death.  Toxicol Appl Pharmacol 111: 242-254, 1991.

 

47. Corcoran GB, Ray SD:  Damage to the nucleus and acute cell death produced by alkylating hepatotoxins.  In: Molecular Theories of Cell Life and Death, S Ji, ed, Rutgers University Press, New Brunswick, NJ, pp 384-400, 1991.

 

48. Shen W, Kamendulis LM, Ray SD, Corcoran GB:  Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Effects of Ca2+-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death.  Toxicol Appl Pharmacol 112: 32-40, 1992.

 

49. Burchiel SW, Davis DP, Ray SD, Sorge CL, Archuleta M, Thilsted J, Corcoran GB:  DMBA-Induced cytotoxicity in lymphoid and nonlymphoid organs of B6C3F1 mice: relation of cell death to target cell intracellular calcium and DNA damage.  Toxicol Appl Pharmacol  13: 126-132, 1992.

 

50. Salazar DE, Shentag JJ, Corcoran GB:  Obesity as a risk factor in drug-induced organ injury. V Toxicokinetics of gentamicin in the obese overfed rat.  Drug Metab Dispos 20: 402-406, 1992.

 

51. Corcoran GB, Ray SD:  Contemporary Issues - The role of the nucleus and other compartments in acute cell death produced by alkylating hepatotoxicants.  Toxicol Appl Pharmacol 113: 167-83, 1992.

 

52. Ray SD, Sorge CL, Kamendulis LM, Corcoran GB:  Ca2+-Activated DNA fragmentation and dimethylnitrosamine-induced hepatic necrosis: Effects of Ca2+-endonuclease and poly(ADP-Ribose) polymerase inhibitors in mice.  J Pharmacol Exp Ther  63: 387-394, 1992.

 

53. Kamendulis LM, Corcoran GB:  Independence and additivity of cultured hepatocyte killing by Ca2+ overload and ATP depletion.  Toxicol Lett 63: 277-287, 1992.

 

54. Ray SD, Kamendulis LM, Gurule MW, Yorkin RD, Corcoran GB:  Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.  FASEB J 7: 453-463, 1993.

 

55. Kraner JC, Lasker JM, Corcoran GB, Ray SD, Raucy JL:  Induction of P450IIE1 by acetone in isolated rabbit hepatocytes involves increased protein synthesis.  Biochem Pharmacol 45: 1483-1492, 1993.

 

56. Ramzan I, Wong BK, Corcoran GB:  Pain sensitivity in dietary-induced obesity.  Physiol Behav 54: 433-435, 1993.

 

57. Salazar DE, Sorge CL, Jordan SW, Corcoran GB:  Obesity decreases hepatic glutathione and increases allyl alcohol-induced periportal necrosis in the obese overfed rat.  Intl J Obesity 18: 25-33, 1994.

 

58. Corcoran GB, Fix LF, Jones DP, Moslen MT, Nicotera P, Oberhammer FA, Buttyan R:  Contemporary Issues.  Apoptosis: Molecular control point in toxicity.  Toxicol Appl Pharmacol 128: 169-181, 1994.

 

59. Kamendulis LM, Corcoran GB:  DNA as a critical target in toxic cell death: potentiation of dimethylnitrosamine toxicity in cultured mouse hepatocytes by DNA repair inhibitors.  J Pharmacol Exp Ther 271: 1695-1698, 1994.

 

60. Fischer-Nielsen A, Corcoran GB, Poulsen HE, Kamendulis LM, and Loft S:  Menadione induced DNA fragmentation without 8-hydroxy-2'-deoxyguanosine formation in isolated rat hepatocytes.  Biochem Pharmacol 49: 1469-1474, 1995.

 

61. Kamendulis LM, Shen W, Ray SD, Corcoran GB:  Dimethylnitrosamine-induced cytotoxicity in cultured mouse hepatocytes.  J Toxicol Environ Health  46: 31-46, 1995.

 

62. Johnston DE, Marcadis D, Corcoran GB, DeBetta M, Salas VM, Ramos HC: Purification of primary human hepatocytes using Ricin A chain.  In Vitro Cell Dev Biol 32: 388-390, 1996.

 

63. Salas VM, Corcoran GB: Ca2+-Dependent DNA damage and cAMP-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.  Hepatology 25: 1432-1438, 1997.     http://www3.interscience.wiley.com/cgi-bin/fulltext/106594724/PDFSTART

 

64. Bezin L, Anastasiadis PZ, Corcoran GB, Nygaard TG, Levine RA: Tetrahydrobiopterin metabolism in cell death by apoptosis. In: Chemistry and Biology of Pteridines and Folates, H Rokos and W Pfleiderer

(Eds), Blackwell Publishers, Berlin, pp 747-754, 1997.

 

65. Groc L, Jackson-Hunter T, Jiang H, Bezin L, Koubi D, Corcoran GB, and Levine RA:  Nitric oxide synthase inhibition during development: effect on apoptotic death of dopamine neurons. Dev Brain Res 138: 147-153, 2002.

 

66. Jiang H, Koubi D, Groc L, Hunter T, Anastasisdis PZ, Rodriguez AI, Corcoran GB, Levine RA: The role of tetrahydrobiopterin (BH4) in apoptosis of catecholamine (PC12) cells induced by trophic factor withdrawal. In: Chemistry and Biology of Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds), Kluwer Academic Publishers, Boston/Dordrecht/London, pp 405-408, 2002.


67. Koubi D, Jiang H, Hunter T, Anastasisdis PZ, Rodriguez AI, Corcoran GB, Levine RA. The involvement of tetrahydrobiopterin in ischemia-induced apoptosis. In: Chemistry and Biology of Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds), Kluwer Academic Publishers, Boston-Dordrecht-London, pp. 409-413, 2002.

 

68. Koubi D, Jiang H, Hunter T, Rodriguez AI, Corcoran GB, Levine RA: Tetrahydrobiopterin (BH4) mediates necrotic death of PC12 cells exposed to ischemia-like conditions. In: Pterins, Folates, and Neurotransmitters in Molecular Medicine, SPS Verlagsgesellscraft mbH, Heilbronn, Germany, pp. 35-40, 2003.

 

69. Leslie SW, Corcoran GB, MacKichan JJ, Undie AS, Vanderveen RP, Miller KW. Pharmacy Scholarship Reconsidered: The Report of the 2003-2004 Research and Graduate Affairs Committee. Am J Pharm Educ   68: S6, 2004.

 

70. Koubi D, Jiang H, Zhang L, Tang W, Kuoa J, Rodriguez AI, Jackson-Hunter T, Seidman MD, Corcoran GB, Levine RA: Role of the Bcl-2 family of proteins in mediating apoptotic death of PC12 cells exposed to oxygen and glucose deprivation.  Neurochem Intl 46: 73-81, 2005.

 

71. Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA.  Resvetratrol-induced apoptotic cell death in human U251 glioma cells. Mol. Cancer Therapeutics 4: 554-561, 2005.

 

72. Corcoran GB.  Obesity as an Occult Risk Factor in Drug- and Chemical-Induced Toxicities.  In: “Phytopharmaceuticals for Obesity Treatment: Pathophysiology and Weight Management," Debasis Bagchi and Harry Preuss, eds., CRC Press, Boca Raton, FL, pp 165-173, 2007.

 

73. Ray SD, Corcoran GB.  Cell death and apoptosis.  In: "General and Applied Toxicology," B. Ballantyne, T. Marrs and T. Syversen, Eds, Nature Publishers, Vol 1, pp. 247-312, 2009.

 

74. Patel N, Joseph C, Corcoran GB, Ray SD.  Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL, and p53 expression while preventing apoptotic and necrotic death in the liver. Toxicol Appl Pharmacol 245: 143-152, 2010.

 

75. Hirata A, Corcoran GB, Hirata F:  Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.  Toxicol Appl Pharmacol 248: 45-51, 2010.

 

76. Hirata A, Corcoran GB, Hirata F:  Carcinogenic heavy metals As3+ and Cr6+ increase nuclear mono-ubiquinated annexin A1 affinity for DNA containing 8-oxo-guanosine and promote translesion DNS synthesis Toxicol Appl Pharmacol 252: 159-164, 2011.

 

77. Ismail S, Tathod J, Parmar M, Corcoran GB, Ray SD:  Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury.  Molec Cell Biochem Accepted, 2012, DOI 10.1007/s11010-012-1277-z.

 

78. Corcoran GB.  The obese and overweight: A new sensitive population for drug and chemical toxicities ?.  In: "Obesity: Epidemiology, Pathophysiology and Prevention," Debasis Bagchi and Harry Preuss, eds., CRC Press, Boca Raton, FL, 2012.

 

79. Hirata F, Corcoran GB, Hirata A: “Mono-Ubiquitination of Nuclear Annexin A1 and Mutagenesis,” in Mutagenesis, Rajnikant Mishra, Editor, Intech, 2012.  http://dx.doi.org/10.5772/50800

 

80. Ray, SD, Betharia S, Farris F, Corcoran GB, Ray SD: Mechanisms of Toxicity, in Encyclopedia of Toxicology, 3rd edition, Philip Wexler, Editor, 2014, In Press.

 

81. Corcoran GB, Ray SD: Benzyl Alcohol, in Encyclopedia of Toxicology, 3rd edition, Philip Wexler, Editor, 2014, In Press.

 

82. Hirata A, Harada T, Corcoran GB, Hirata F Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis..  Mutat Res, 2014, Accepted

 

 


Primary Research Interest

Research interests are multidisciplinary and translational.  They focus on cellular injury and cell death, as well as factors governing drug and chemical-induced injuries, including drug metabolism and nutrition.  Approaches designed to translate basic discoveries to improve human health involve integrated in vivo models, cellular and molecular biology, pharmacokinetics, synthetic chemistry, and retrospective and prospective clinical investigation of human volunteers and patients.  Specific areas of investigation include cell death by necrosis and apoptosis, the role of DNA damage in acute cell death, drug and chemical injury to the liver, role of nutrition and obesity in drug and chemical injury, drug biotransformation including by CYPs, and particularly the toxicity of acetaminophen (paracetamol).


Personal Interests

Member, Knox United Presbyterian Church Sanctuary Choir (1981-88)

Volunteer, The American Cancer Society (1983-88)

President, Knox United Presbyterian Church Sanctuary Choir (1985-88)

Member, The Knox Choraliers (outreach vocal group ministering to the disadvantaged) (1981-88)

Member, Treasury Committee, The Knox Choraliers (1985-88)

Spokesperson, Concerned Citizens of Kenmore (1983-85)

Block Captain, Neighborhood Watch Group (1983-88)

Mock Trial Participant, University of New Mexico School of Law (1993)

Assistant Coach and Volunteer, Albuquerque Youth Soccer Organization (1994-96)

Volunteer, Boy Scouts of America, New Mexico Council (1993-96)

Pro Bono Toxicology Consultation, State of New Mexico Public Defenders Offices (1991-96)

Assistant Coach and Volunteer, Albuquerque Youth Basketball League (1994-96)

Volunteer, Boy Scouts of America, Detroit Area Council (1997-1999)

Assistant Den Leader, Boy Scouts of America, Detroit Area Council (1999-2002)

   Deacon, First Presbyterian Church, Northville, MI (2000-2003)

   Outreach Committee, First Presbyterian Church, Northville, MI (2000-)

   Volunteer, Habitat for Humanity (2000-)

   Volunteer, Gleaners Community Food Bank (1999-)

   Volunteer, Fort Street Presbyterian Church Open Door Mission (1999-)

   Regional Organizer, Crop Walk, Church World Services (2000-)

   Elder, First Presbyterian Church, Northville, MI (2003-2006)

   Member of Session, First Presbyterian Church, Northville, MI (2003-2006)

   Moderator, Nominating Committee, First Presbyterian Church, Northville, MI (2003-2006)

   Coach, Quad Cities Baseball League (2003-4)

   Personnel Search Committee, Member, First Presbyterian Church, Northville, MI (2003-2004)

   Moderator, Mission & Outreach Committee, First Presbyterian Church, Northville, MI (2004-2006)

   Founding Member, Centers for Intentional Community, Detroit, MI (2004-)


Responsibilities

EDITORIAL BOARDS AND REFEREEING 

     Editorial Boards

 

     Toxicology and Applied Pharmacology Toxicology and Applied Pharmacology

            (Associate Editor 2002-Date, Member 1993-1996)

     Basic and Clinical Pharmacology and Toxicology (Member, 2002-2012)

     Pharmacology and Toxicology (Member, 1993-2002)
 
     Toxicology Letters (Member, 1993-1997)

     Journal of Toxicology and Environmental Health (Member, 1992-1998)

     Ad Hoc Journal and Monograph Review

        American Journal of Pathology

        American Journal of Physiology

        Alcoholism: Clinical and Experimental Research

        Archives of Biochemistry and Biophysics                        

        Biochemical Pharmacology

        Biopharmaceutics and Drug Disposition

        Blood

        Canadian Journal of Physiology and Pharmacology

        Cellular and Molecular Biology

        Chemical Research in Toxicology

        Chemico-Biological Interactions

        Clinical Pharmacology and Therapeutics

        CRC Monographs

        DICP, The Annals of Pharmacotherapy

        Drug Metabolism and Disposition

        Experimental Cell Research

        Fundamental and Applied Toxicology

        Gastroenterology

        Hepatology

        International Journal of Obesity

        International Journal of Pharmaceutics

        Journal of Basic and Clinical Pharmacology

        Journal of Clinical Investigation

        Journal of Histochemistry and Cytochemistry

        Journal of Medicinal Chemistry

        Journal of Pediatric Gastroenterology and Nutrition                     

        Journal of Pharmaceutical Sciences

        Journal of Pharmacology and Experimental Therapeutics          

        Journal of Toxicology and Environmental Health

        Life Sciences

     Molecular Pharmacology

        Pharmacology and Toxicology

        Research Communications in Chemical Pathology and Pharmacology

        Toxicological Sciences

        Toxicology

        Toxicology and Applied Pharmacology

        Toxicology In Vitro

        Toxicology Letters


PUBLIC ADVISORY GROUPS 

        National Research Council Hughes Howard Pre-Doctoral Fellowships Neurology & Physiology 1

            Panel, National Academy of Sciences - Member 2000-Date

        Texas Higher Education Coordinating Board External Review Consultant for Texas Southern University MS and PhD in Pharmaceutical Sciences - 2004

        Center for Research on Environmental Disease, University of Texas Austin and MD Anderson Cancer Center, Pilot Programs - External Reviewer 2004

        Biochemical Sciences (BCS-IRG) Special Emphasis Panel Study Section - Member 2000

        Veterans Administration Merit Review Comm, Office of External Review - Ad Hoc Member 2000

        Hans W. Vahlteich Endowed Research Program, University of Illinois  - Reviewer 1999

        Alcohol/Toxicology-1 Study Section, National Institutes of Health - Member 1996-2002

        Multidisciplinary Special Emphasis Panel, National Institutes of Health - Member 1997

        University of Puerto Rico MBRS Program Review - Ad Hoc Reviewer 1997

        Multidisciplinary Special Emphasis Panel, National Institutes of Health - Chair 1997

        Veterans Administration, Eastern Research and Development Office - Ad Hoc Reviewer 1992-1996

        Veterans Administration, National Research and Development Office - Ad Hoc Reviewer 1999-Date

        Medical Research Council of Canada – Ad Hoc Reviewer 1984-

        Foundation for Advancement of Science Technology – Ad Hoc Reviewer 1985-

        Henry Ford Hospital Research Administration – External Reviewer 1986-

        University of California Coordinating Committee on Graduate Affairs – External Reviewer 1985

        American Cancer Society University of New Mexico Research Starter Grants 1992-4; 1994-1996

        Internal Advisory Board, Epidemiology and Toxicology of Lung Disease Training Grant, UNM 1996