Robert T. Louis-Ferdinand

Cardinal Hayes High School , New York , New York Graduated 1955
St. Francis College , New York , New York B.S. (Chemistry - 1959)
University of Rhode Island , Kingston , Rhode Island M.S. (Pharmacology - 1969) (Ph.D. - 1970)

Research Biochemist - U.S. Army Research
Institute of Environmental Medicine
Natick , Massachusetts
1963 - 1966

Assistant Professor of Pharmacology and Toxicology
University of Maryland , School of Pharmacy
Baltimore , Maryland
1970 - 1975

Associate Professor of Pharmacology and Toxicology
University of Maryland , School of Pharmacy
1975 - 1976, Continuing Tenure 1975

Professor of Pharmacology, Coordinator of
Pharmacology Education
Wayne State University , College of Pharmacy
and Allied Health Professions
Detroit , Michigan
1976 - 1983, Continuing Tenure 1977

Visiting Professor, Industrial Toxicology Unit,
Catholic University of Louvain ,
Brussels , Belgium
October 1982 - October 1983

Positions Held: Acting Chairman,
Department of Pharmaceutical Sciences,
College of Pharmacy and Allied Health Professions
Wayne State University , Detroit , Michigan
January 1, 1984 - March 1, 1986 ; June 1, 1987 - July 1, 1988

Professor of Pharmacology,
Department of Pharmaceutical Sciences,
College of Pharmacy and Allied Health Professions
Wayne State University ,
Detroit , Michigan
March 1, 1986 - Present

American Society of Pharmacology and Experimental Therapeutics
Society of Toxicology

College Committee
Graduate programs in Pharmaceutical Member
Physical Therapy Chair Performance
Academic and Professional Progress Committee
Radiation Technology Chair Performance Review
Promotion and Tenure Committee
Occupational Therapy Chair Performance Review

University Committee
Human and Animal Research
Graduate Council
P h.D. Program Review
Graduate Scholarship and Fellowship Awards
Research Evaluation Member
Promotion and Tenure Member
Medical School Dean Performance Evaluation Committee Member

Professional
Society of Toxicology Member Session of Drug Toxicity
Session on Drug Toxicity
Session on Metals
Toxicology and Applied Pharmacology Reviewer
National Science Foundation Graduate Fellowship Review Panel National Institute on Drug Abuse Biomedical Research Review Committee Member

Official Commendation: U.S. Army Research Institute of Environmental Medicine (1955)

Outstanding Instructor Award, Wayne State University (1978) (1979) (1981) (1982) (1984) (1986) (1990) (1993) (1994)

Excellence in Teaching Award Wayne State University (2000) (2001)

Ford Foundation Fellowship, National Academy of Sciences (1982-1983)

   1.  Conney, D.P., Blatt, W.F., Louis-Ferdinand, R.T. and Smith, B.S.: Studies on Thrombopoesis II, Effect of a Non-Dialyzable Spleen Preparation on the Thrombocyte Level. Scand. J. Haematol. 2: 195 (1965).
   2. Robinson, S.M., Hurwitz, D.A., Louis-Ferdinand, R.T. and Blatt, W.F.: Hemodialysis of the Rat. Can. J. Physiol. and Pharmacol. 44 : 849 (1966).
   3. Louis-Ferdinand, R.T., Therriault, D.G., Blatt, W.F. and Mager, M.: Application of Thin-Layer Chromatography to the Quantitation of Plasma Neutral Lipids and Free Fatty Acids. Clin. Chem. 13: 773 (1967).
   4. Louis-Ferdinand, R.T. and Blatt, W.F.: Quantitative Immunoassay by Disc Electrophoresis. Clin. Chem. Acta 16: 259 (1967).
   5. Louis-Ferdinand, R.T. and Fuller, G.C.: Reactivity of 5,5' Dithiobis (2-Nitro-Benzoic Acid) with Sulfhydryl Compounds in the Presence of Molluscicidal Nitroolefins and Organomercurials, (The Pharmacologist, 10: 215 (1968).
   6. Fuller, G.C. and Louis-Ferdinand, R.T.: Relationship Between Sulfhydryl Reactivity and Inhibition of In Vitro Oxygen Uptake by Molluscicidal Nitrostyrene Derivatives. Toxicol. and Appl. Pharmacol., 14: 663 (1969). Louis-Ferdinand, R.T. and Fuller, G.C.: A Rate Assay for the Estimation of Thiol Reactivity. J. Pharm. Sci., 58: 1155, (1969).
   7. Louis-Ferdinand, R.T. and Fuller, G.C.: Suppression of Hepatic Ribonuclease During Phenobarbital Stimulation of Drug Metabolism. Biochem. Biophys. Res. Communs. 38: 811 (1970).
      Louis-Ferdinand, R.T. and Fuller, G.C.: Inhibition of Hepatic Ribonuclease Activity During Phenobarbital Induction. Fed. Proc., 29: 737 (1970).
   8. Louis-Ferdinand, R.T. and Fuller, G.C.: The Mechanism of the Biological Activity of a Series of Nitroolefins. Toxicol. and Appl. Pharmacol., 16: 668 (1970).
   9. Louis-Ferdinand, R.T., Puri, S., Kowal, F., Fuller, G.C. and Lal, H.: Inhibition of Drug Metabolism by Amphetamine, Methamphetamine, Hydoxyamphetamine and Chloramphetamine. Toxicol. and Appl. Pharmacol., 17: 287 (1970).
  10. Louis-Ferdinand, R.T., Cutroneo, K.R. Kosgarten , D.C. Defanti, D.R. and Turcotte, R.C.: Flow Decrease Through Rat Hind Limb Vasculature by (+/-) Carnitine (+/-) Acetylcarnitine. J. Pharmacy and Pharmacology, 22: 704 (1970).
  11. Cutroneo, K.R. Louis-Ferdinand, R.T., Vasavada, R.C., Turcotte, J.G. and Defanti, D.R.: Vagotomy and Artopine Antagonism of (+/-) Chloroacetyl Carnitine Chloride Mediated Blood Pressure Reduction in the Rat. J. Pharmacy and Pharmacology, 22: 940 (1970).
  12. Louis-Ferdinand, R.T. and Fuller, G.C.: Early Liver Microsomal Ribonuclease Suppression During Induction of Drug-Metabolizing Enzymes by Phenobarbital. The Pharmacologist. 12: 278 (1970).
  13. Louis-Ferdinand, R.T. and Fuller, G.C.: Induction of Liver Microsomal Drug Metabolism and Inhibition of Microsomal Ribonuclease by Phenobarbital. Toxicol. and Appl. Pharmacol. 23: 492 (1972).
  14. Louis-Ferdinand, R.T., Fuller, G.C. and Lal, H.: Amphetamine Inhibition of Hepatic Drug Metabolism: Evidence for a Competitive Mechanism. Clin. Toxicol. 5: 387 (1972).
  15. Louis-Ferdinand, R.T. and Chapman, S.K.: Modification of Dimethylmercury Toxicity by Phenobarbital. Fed. Proc., 31: 561 abs. (1972).
  16. Louis-Ferdinand, R.T.: Reduction of Hepatic Microsomal RNA Degradation by Cycloheximide. The Pharmacologist, 16: 255 (1974).
  17. Crossley, H.L., Bert, J.D., Burgison, R.M. and Louis-Ferdinand, R.T.: Antihistamine-Induced Potentiation of Barbiturate Narcosis in Rats and Mice. J. Dental Res., 53: 104 (1974).
  18. Louis-Ferdinand, R.T.: Liver Microsomal Ribonuclease Reduction by Phenobarbital, Following Pretreatment with Inhibitors of Protein Synthesis. Fed. Proc., 33: 546 (1974).
  19. Louis-Ferdinand, R.T.: Influence of Barbiturate Analogues on Liver Microsomal RNA Degradation During Development of Metabolic Tolerance. Toxicol. and Appl. Pharmacol., 29: 114 (1974).
  20. Louis-Ferdinand, R.T.: Reduction of Rat Liver Microsomal Ribonuclease by Cycloheximide. Mol. Pharmacol., 11: 185 (1975).
  21. Louis-Ferdinand, R.T.: Reduction of Hepatic Microsomal Ribonuclease Activity by Phenobarbital and Gamma-Hexachlorocyclohexane (lindane) in Adult Rats and Mice. The Pharmacologist, 17: 183 (1975).
  22. Navran, S.S. and Louis-Ferdinand, R.T.: P-Chloro-N-Methyl-aniline Demethylation by Rat Kidney Subcellular Fractions. Res. Commun. Chem. Pathol. Pharmacol., 12: 713 (1975).
  23. Brown, D.R., Klein, A.W. and Louis-Ferdinand, R.T.: Effect of lead on Behavioral, Morphological and Biochemical Indices of Development in the Neonatal Rat Brain. Toxicol. and Appl. Pharmacol., 37: 191 (1976).
  24. Klein, A.W., Louis-Ferdinand, R.T. and Brown, D.R.: Measurement of Behavioral, Chemical and Anatomical Changes in the Developing Rat Brain from Exposures to Low Levels of Lead. The Anatomical Record, 187: 626 (1977).
  25. Louis-Ferdinand, R.T.: Barbiturates and Psychotherapy in Psychotherapeutic Drugs Vol. II, E. Usdin and I. Forrest, Editors. Marcel Dekker Inc., New York , 1317-1337 (1977).
  26. Gerson, R.J., Louis-Ferdinand, R.T.: Effect of Daily Actinomycin-D Treatment on Food Consumption and 14C- Orotic Acid Incorporation into Heptic RNA. The Pharmacologist, 19: 183 (1977).
  27. Daughtrey, W.C., Brown, D.R. and Louis-Ferdinand, R.T.: Inhibition by Lead of Butyryl Cholinesterase and Gamma-Glutamyltranspeptidase in the Developing Neonatal Rat Brain. Proc. First Internat.. Congress on Toxicol.: Toxicology as a Predictive Science, 498, Gabriel L. Plaa and W.A.M. Duncan, Eds. Academic Press, New York (1978).
  28. Louis-Ferdinand, R.T., Brown, D.R., Fidler, S.F., Daughtery, W.C. and Klein, A.W.: Morphometric and Enzymatic Effects of Neonatal Lead Exposure in the Rat Brain. Toxicol. and Appl. Pharmacol., 43:351 (1978).
  29.

      Louis-Ferdinand, R.T., Stout, M.K. and Beuthin, F.C.: Inhibition of Brain and Kidney Gamma-Glutamyltranspeptidase Following Lead Acetate Administration. The Pharmacologist, 20: 179 (1978).
  30. Gaddis, R.R. and Louis-Ferdinand, R.T.: Stimulation of Renal and Hepatic 5'-Phosphodiesterase Activity by Folic Acid Administration in the Rat. The Pharmacologist, 20: 182 (1978).
  31. Louis-Ferdinand, R.T., Beuthin, F.C. and Stout, M.K.: Enhancement of Hexobarbital and Barbital Hyposis by Diphenhydramine. Toxicology and Applied Pharmacology, 45: 355 (1978).
  32. Gaddis, R.R. and Louis-Ferdinand, R.T.: Biphasic Response of Renal 5' Phosphodiesterase Following Folic Acid administration in the Rat. Toxicol. Appl. Pharmacol., 48, A22 (1979).
  33. Louis-Ferdinand, R.T., Beuthin, F.C., Roginski, E. and Stout, M.K.: Enhancement of Hexobarbital Hypnosis by Diphenhydramine Methylammonium Bromide and Diphenhydramine. Toxicol. Appl. Pharmacol., 48 A96 (1979).
  34. Louis-Ferdinand, R.T. and Beuthin, F.C.: Delayed Development of Brain Gamma-Glutamyl Transpeptidase Activity in the Lead Exposed Neonatal Rat. Federation Proc., 39, 623 (1980).
  35. Scheri, R., Beuthin, F.C. and Louis-Ferdinand, R.T.: Age Related Difference in Gamma-Glutamyl Transpeptidase Inhibition by Lead in Vitro. The Toxicologist, 1, 118 (1981).
  36. Konantakieti, C., Roginski, E.T. Beuthin, F.C., and Louis-Ferdinand, R.T.: Erythrocyte Pyrimidine 5'-Neucleotidase (P5N) Inhibition in the Lead Exposed Neonatal Rat. Federation Proc., 40 701 (1981).
  37. Stout, M.L., Marrazzi, M., Louis-Ferdinand, R.T. and Beuthin, F.C.: Glycolytic Correlates of Tolerance to Intraventricular (ICV) Phenobarbital (PB) in Mice. Federation Proc., 40 (3) 296 (1981).
  38. Gaddis, R.R., Louis-Ferdinand, R.T., and Beuthin, F.C.: Differential Effects of Folic Acid on Rat Kidney Water Content, Protein and Microsomal 5' -Phosphodiesterase Activity. Food and Chem. Toxicol., 20 159 (1982).
  39. Louis-Ferdinand, R.T., Glass, L., Sharp, R., and Beuthin, F.C.: Altered Lead Distribution in Thiamin-Treated Rodents. The Toxicologist, 2 (1982).
  40. Roginski, E.T., Beuthin, F.C., Louis-Ferdinand, R.T. and Marengos, P.J.: Increased Neuron Specific Enolase (NSE) Levels in Rat Brain Stem Following Perinatal Lead Treatment. The Toxicologist, 2, 56 (1982).
  41. Scheri, R., Beuthin, F.C., and Louis-Ferdinand, R.T.: Effect of Lead Acetate on the Kinetics of Gamma-Glutamyl Transpeptidase Activity from Neonatal Rat Pup Brain Drug and Chemical Toxicology, 4, 363 (1982).
  42. Nagelhout, J.J., Beuthin, F.C. and Louis-Ferdinand, R.T.: The Effect of Trace Halothane on 2'3' Cyclic Nucleotide 3' Phosphodiesterase (CNPase) in the Developing Rat Brain. The Toxicologist, 2, 155 (1982).
  43. Lauwerys, R., and Louis-Ferdinand, R.T.: Human Toxicology: The Need for a Closer Collaboration Between Clinical and Experimental Toxicologists. Human Toxicology, 3, 61 (1984).
  44. Rosen, J.B., Berman, R.F., Beuthin, F.C., and Louis-Ferdinand, R.T.: Age of Testing as a Factor in the Behavioral Effects of Early Lead Exposure in Rats. Pcol. Biochem. and Behav., 23, 49-54, (1985).
  45. Rosen, J.B., Young, A.M., Beuthin, F.C., and Louis-Ferdinand, R.T.: Discriminative Stimulus Properties of Amphetamine and Other Stimulants in Lead-Exposed and Normal Rats. Pcol. Biochem. and Behav., 24, 211-215 (1986).
  46. Nagelhout, J.J., Louis-Ferdinand, R.T. and Beuthin, F.C. Effect of Halothane on Brain 2', 3'-Cyclic Nucleotide 3'-Phosphodiesterase During Neurodevelopment in the Rat. Res.Commun. Chem. Pathol. Pharmacol. 53 261-265 (1986).
  47. Konantakieti, C., Beuthin, F.C. and Louis-Ferdinand, R.T., Erythrocyte Pyrimidine 5' -Nucleotidase Inhibition by Acute Lead Exposure in Neonatal Rats. J. Biochem. Toxicol. 1, 51-59 (1986).
  48. Konantakieti, C., Beuthin, F.C. and Louis-Ferdinand, R.T., Erythrocyte Pyrimidine 5" -Nucleotidase Lead Resistance. The Toxicologist 9, 101 (1989).
  49. Buss, N. and Louis-Ferdinand, R.T., Autonomic Drug Response Simulation by Microcomputer. The Pharmacologist 32: 191 (1990).
  50. Matchikowski, S.J. and Louis-Ferdinand, R.T., Dissociation of Plasma Sorbitol Dehydrogenase and Liver Thiobarbituric Acid Index by Acute Ethanol. The Pharmacologist 32: 130 (1990)
  51. Louis-Ferdinand, R.T., Naganuma, Y., Gogi, Y. and Imura, N., Plasma Enzyme Increases and Hepatic Lipid Peroxidation by Acute Ethanol. The Toxicologist 12: 63 (1992).
  52. Lourwood, D.L., Berchou, R. and Louis-Ferdinand, R.T. Diminished Mephobarbital Anticonvulsant Action following Diphenhydramine Pretreatment. Research Communs. Chem. Pathol. Pharmacol. 77: 273 (1992).
  53. Garner, C.D., Lee, E.W. and Louis-Ferdinand, R.T., Role of Retinal Metabolism in Methanol-Induced Retinal Toxicity. The Toxicologist 14: 56 (1994).
  54. Louis-Ferdinand, R.T., Myelotoxic, Neurotoxic and Reproductive Adverse Effects of Nitrous Oxide. Adv. Drug Reactions and Tox. Revs. 13(3): 243 (1994).
  55. Garner, C.D., Lee, E.W. and Louis-Ferdinand, R.T., Muller Cell Involvement in Methanol-Induced Retinal Toxicity., Toxicol. Appl. Pharmacol. 130: 101 (1995).
  56. Garner, C.D., Lee, E.W. and Louis-Ferdinand, R.T., Role of Retinal Metabolism in Methanol-Induced Retinal Toxicity., J Toxicol. Env. Hlth. 195: 43 (1995).
  57. Garner, C.D., Lee, E.W., Terzo, T.S. and Louis-Ferdinand, R.T., Role of the Muller Cell in Methanol-Induced Retinal Toxicity. The Toxicologist 15: 21 (1995).