State University of New York at Buffalo (1990) B.A. Psychology
State University of New York at Buffalo (1990) B.S. Biological Sciences
Wayne State University (1999) Ph.D. Biological Sciences
University of Michigan (1999-2002) Post-Doctoral Fellow, Dept. of Cell and Developmental Biology
2007- Assistant Professor, Wayne State University, Dept. of Pharmaceutical Sciences
2004- Health Science Specialist, John D. Dingell V.A. Medical Center
2003-2007 Assistant Professor (Research), Wayne State University School of Medicine,
Dept. of Psychiatry & Behavioral Neurosciences
1999-2002 Post-Doctoral Fellow, University of Michigan, Dept. of Cell and Developmental Biology
1994-1999 Graduate Research Assistant and Graduate Teaching Assistant, Wayne State University,
Dept. of Biological Sciences
1992-1994 Research Associate, Wayne State University, Dept. of Psychology
1990-1992 Research Assistant, State University of New York at Buffalo, Dept. of Psychology
Member, American Society for Pharmacology and Experimental Therapeutics
Member, New York Academy of Sciences
Member, Society for Neuroscience
Member, Society of Toxicology
Yu T, Thomas DM, Zhu W, Goodman M, Gumucio DL. (2002) Regulation of Fetal vs. Embryonic Gamma Globin Genes: Appropriate Developmental Stage Expression Patterns in the Presence of HS2 of the Locus Control Region. Blood 99:1082-1084.
Thomas DM, Francescutti-Verbeem DM, Liu X, Kuhn DM. (2004) Identification of Differentially Regulated Transcripts in Mouse Striatum Following Methamphetamine Treatment – an Oligonucleotide Microarray Approach. J. Neurochem. 88:380-393.
Thomas DM, Walker PD, Benjamins JA, Geddes TJ, Kuhn DM. (2004) Methamphetamine Neurotoxicity in Dopamine Nerve Endings of the Striatum is Associated with Microglial Activation. J. Pharmacol. Exp. Ther. 311:1-7.
Thomas DM, Dowgiert J, Geddes TJ, Francescutti-Verbeem D, Liu X, Kuhn DM. (2004) Microglial Activation is a Pharmacologically Specific Marker for the Neurotoxic Amphetamines. Neurosci. Lett. 367:349-354.
Thomas DM, Kuhn DM. (2005) Attenuated Microglial Activation Mediates Tolerance to the Neurotoxic Effects of Methamphetamine. J. Neurochem. 92:790-797.
Thomas DM, Kuhn DM. (2005) Cyclooxygenase-2 is an Obligatory Factor in Methamphetamine-Induced Neurotoxicity. J. Pharmacol. Exp. Ther. 313:870-876.
Thomas DM, Kuhn DM. (2005) MK-801 and Dextromethorphan Attenuate Microglial Activation and Protect Against Methamphetamine-Induced Neurotoxicity. Brain Res. 1050:190-198.
Thomas DM, Francescutti-Verbeem DM, Kuhn DM. (2006) Gene Expression Profile of Activated Microglia Under Conditions Associated with Dopamine Neuronal Damage. FASEB J. 20:515-517.
Sakowski SA, Geddes TJ, Thomas DM, Levi E, Hatfield JS, Kuhn DM. (2006) Differential Tissue Distribution of Tryptophan Hydroxylase Isoforms 1 and 2 as Revealed with Monospecific Antibodies. Brain Res. 1085:11-18.
Kuhn DM, Francescutti-Verbeem DM, Thomas DM. (2006) Dopamine Quinones Activate Microglia and Induce a Neurotoxic Gene Expression Profile: Relationship to Methamphetamine-Induced Nerve Ending Damage. Ann. NY Acad. Sci. 1074:31-41.
Thomas DM, Francescutti-Verbeem DM, Kuhn DM. (2008) The Newly Synthesized Pool of Dopamine Determines the Severity of Methamphetamine-Induced Neurotoxicity. J. Neurochem. 105:605-616.
Thomas DM, Francescutti-Verbeem DM, Kuhn DM. (2008) Methamphetamine-Induced Neurotoxicity and Microglial Activation are Not Mediated by Fractalkine Receptor Signaling. J. Neurochem. 106:696-705.
Kuhn DM, Francescutti-Verbeem DM, Thomas DM. (2008) Dopamine Disposition in the Presynaptic Process Regulates the Severity of Methamphetamine-Induced Neurotoxicity. Ann. NY Acad. Sci. 1139:118-126.
Thomas DM, Francescutti-Verbeem DM, Kuhn DM. (2009) Increases in Cytoplasmic Dopamine Compromise the Normal Resistance of the Nucleus Accumbens to Methamphetamine Neurotoxicity. J. Neurochem. 109:1745-1755.
