Current Research
Pharmacy Practice
- Atrial Fibrillation and the Renin-Angiotensin-Aldosterone System
University Research Grant Kalus(PI) 05/01/2004 - 05/01/2005
Wayne State University
The objective of this study is to determine whether atrial fibrillation causes elevations in angiotensin II and angiotensin-convertin-enzyme and wheter these neurohormones play a role in perpetuation of atrial fibrillation.
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Ventricular Defibrillation
Small Grants Open Competition McBride(PI) 8/01/03-4/01/04
Hartford Hospital Research Foundation
Ventricular Defibrillation Threshold Impact of Catecholamines II (DTECT II)
The objective of this study was to determine the effect of catecholamine elevations on the defibrillation threshold of implanted cardioverter-defibrillators in patients taking carvedilol.
Role: Co-Investigator
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Atrial Fibrillation Suppression
Open Competition Grant White(PI) 5/01/01 - 7/01/02
Hartford Hospital Research Foundation
Atrial Fibrillation Suppression Trial II
The objective of this study was to evaluate the efficacy and safety of an amiodarone regimen or pacing of the atrial septum, for prevnting the occurrence of atrial fibrillation after cardiac surgery.
Role: Co-Investigator
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Establishment of a pharmacist service for planning affordable therapies
Community Pharmacy Foundation (PI) 1/04-12/05
Establishment of a pharmacist service for planning affordable therapies.
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Meeting the health care needs of a medically underserved urban minority area through a community pharmacy clinic 12/03-12/04
Meeting the health care needs of a medically underserved urban minority area through a community pharmacy clinic.
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Establishment of a new pharmacy practitioner mentoring program in pharmaceutical care services development Michigan Pharmacy Foundation (PI) 3/04-3/05
Establishment of a new pharmacy practitioner mentoring program in pharmaceutical care services development
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Garlic / Warfarin Interaction
“Garlic / Warfarin Interaction”
Principal Investigator: Moser, Lynette
Agency: St. John Hospital Medical Education Type: Residency Project Period 7/1/01 – 6/30/02
This project administered garlic or placebo to patients who were stabilized on warfarin to determine if there is any effect of garlic on INR in anticoagulated patients.
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Acetyl-Cysteine for the Prevention of RadioContrast Induce Renal Toxicity with Cardiac Catheterization
"Acetyl-Cysteine for the Prevention of RadioContrast Induce Renal Toxicity with Cardiac Catheterization."
Principal Investigator: Jas Kahlon, M.D.
Agency: St. John Hospital Medical Education Type: Fellowship Project Period 7/1/01 – 6/30/03
This project administered acetyl cysteine or placebo to patients at risk of renal dysfunction undergoing cardiac catheterization. The endpoints of the study were changes in serum creatinine at 48 and 96 hours.
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Platelet Aggregation and Pharamcokinetics of Aggrenox„¥ Following Administration Through Gastric Tubes
Innovative Technology Grant (2004)- Wayne State University, PI
Platelet Aggregation and Pharamcokinetics of Aggrenox„¥ Following Administration Through Gastric Tubes
Boheringer Ingelheim Pharmaceuticals, Co-author
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Hypernatremic Hyperosmolar State in Acute Brain Injury
Hypernatremic Hyperosmolar State in Acute Brain Injury: Intracranial Pressure Lowering Therapy (Hy-SALT),Society of Critical Care Medicine Joseph F. Dasta Critical Care Outcomes Research Award, Co-author
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Effect of Protein Binding on TD-6424 and THRX-932864, two New Glycopeptides, against 50 Glycopeptide Non-Susceptible Staphylococci including Vancomycin-Resistan
Leuthner KD, Cheung CM, Rybak MJ. Effect of Protein Binding on TD-6424 and THRX-932864, two New Glycopeptides, against 50 Glycopeptide Non-Susceptible Staphylococci including Vancomycin-Resistant Staphylococcus aureus (VRSA) compared to vancomycin, quinupristin/dalfoprisitin, linezolid and daptomycin. Theravance
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An evaluation of daptomycin pharmacodynamics against S. aureus at varying dosage conditions in a simulated endocardial vegetation model and under simulated rena
Rybak M, Huang V, Tsuji B. An evaluation of daptomycin pharmacodynamics against S. aureus at varying dosage conditions in a simulated endocardial vegetation model and under simulated renal impairment. Cubist (8/1/03 – 7/31/05).
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An evaluation of the in vitro activities of various antimicrobials, including investigational agents alone and in combination against Vancomycin-Resistant Staph
Huang V, Tedesco KL, Brown W, Rybak MJ. An evaluation of the in vitro activities of various antimicrobials, including investigational agents alone and in combination against Vancomycin-Resistant Staphylococcus aureus (VRSA) in an in vitro pharmacodynamic model. Elan (3/15/03 – 4/15/04).
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Anticoagulation management, thrombosis, critical care therapeutics
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