Ph.D. David J.P. Bassett
David Bassett, Ph.D. has recently stepped down after 12 years as the chairman of the Department of Occupational and Environmental Health Sciences at Wayne State University. He currently holds adjunct faculty positions in the Departments of Pharmaceutical Sciences and Family Medicine’s - Division of Occupational and Environmental Medicine. He received his baccalaureate degree in biochemistry from University College, London University, U.K. (1970), and an external Ph.D. in pulmonary biochemistry from the Faculty of Science at London University (1978) while working in the Johnson Research Foundation and Department of Physiology at the University of Pennsylvania, Philadelphia, USA. Following a short period as a research associate in the Department of Biophysics and Physiology at Georgetown University, he joined the biomedical research group at Allied Chemical Corporation NJ, while serving on the adjunct faculty in the Department of Experimental Pathology at Columbia University in New York. He came to Wayne State University in 1991, after 11 years on the faculty of the Department of Environmental Health Sciences of the Johns Hopkins University School of Hygiene and Public Health in Baltimore, where he had been Deputy Director of the Environmental Health Sciences Research Center and Director of the Inhalation Exposure Facility.
He is now a graduate program coordinator with responsibilities for the occupational and environmental health MS degree and MPH degree subspecialties. He is engaged mainly in the development of multi-disciplinary problem-based didactic and practicum courses and in the establishment and evaluation of mechanisms for assessing competence-based educational outcomes. He has published extensively in the field of pulmonary and inhalation toxicology and is currently examining the biochemical and patho-physiological determinants associated with the development of inflammatory diseases of the lung resulting from exposures to allergens and other airborne substances found in workplace, home and ambient environments.
D.J.P. Bassett. Ozone-Induced Lung Injury. In: Handbook of Animal Models of Pulmonary Disease Vol I. (Ed. J. Cantor) CRC Press, pp 19-30,1989.
D.J.P. Bassett, C.L. Elbon, and S.S. Reichenbaugh. Respiratory activity of lung mitochondria isolated from oxygen-exposed rats. Am. J. Physiol. [Lung] 263:L439-L445, 1992.
D.J.P. Bassett and S.S. Reichenbaugh. Lung mitochondrial function following oxygen exposure and diethylmaleate-induced depletion of glutathione. Toxicol. Appl. Pharmacol. 115:161-167, 1992.
D.J.P. Bassett and R.A. Roth. The Isolated Perfused Rat Lung Preparation. In: Methods of Toxicology (Ed. R. Watson) CRC Press, pp , 1992.
A.M.K. Choi, C.L. Elbon, S.A. Bruce, and D.J.P. Bassett. Messenger RNA levels of lung extracellular matrix proteins during ozone exposure. Lung. 172:15-30, 1994.
A.H. Schultheis, D.J.P. Bassett and A.D. Fryer. Ozone-induced airway hyper-responsiveness and loss of neuronal M2 muscarinic receptor function. J. Appl. Physiol. 76:1088-1097, 1994.
D.J.P. Bassett, Y. Ishii, H. Yang, C.L. Elbon, L. Otterbein, G. Boswell, and J.S. Kerr. EDU-pretreatment decreases polymorphonuclear leukocyte migration into rat lung airways. Toxicol.Appl.Pharmacol. 127:76-82, 1994.
Y. Ishii, H. Yang, T. Sakamoto, A. Nomura, F. Hirata, S. Hazegawa, and Bassett, D.J.P. Rat alveolar macrophage cytokine production and regulation of neutrophil recruitment following acute ozone exposure. Toxicol. Appl. Pharmacol. 147: 214-223, 1998.
D.J.P. Bassett, C. Elbon-Copps, Y. Ishii, H. Barraclough-Mitchell, and H. Yang. Lung tissue neutrophil content as a determinant of ozone-induced injury. J Toxicol Environ Health Part A. 25;60:513-530, 2000.
D.J.P. Bassett and D.K. Bhalla. Inflammation and Fibrosis In: Pulmonary Immunotoxicology, M. Cohen, J. Zelikoff and R. Schlesinger (Editors). Kluwer Academic Publishers. 2000.
S.P. Sanders, D.J. P. Bassett, S.J. Harrison, D. Pearse, J.L. Zweier, P.M. Becker. Measurements of free radicals in isolated, ischemic lungs and lung mitochondria. Lung. 2000;178(2):105-18.
D.J.P. Bassett, C. Elbon-Copps, S.S. Otterbein, H. Barraclough-Mitchell, M. DeLorme and H. Yang. Inflammatory cell availability affects ozone-induced lung damage. J. Toxicol. Environ .Hlth Part A. 64:547-565, 2001.
M. P. DeLorme, H. Yang, C. Elbon-Copp, X. Gao, H. Barraclough-Mitchell and D.J.P. Bassett Hyperresponsive airways correlate with lung inflammatory cell changes in ozone-exposed rats. J. Toxicol Environ Hlth Part A, 65: 101-118, 2002.
M. P. DeLorme, X. Gao, H. Barraclough-Mitchell, Nicole Reale and D.J.P. Bassett Pulmonary effects of endotoxin contaminated metal working fluid in a rat lung. J. Toxicol Environ Hlth Part A, 66:7-24, 2003
.S. Kannan, P. Kolhe, V. Raykova, M. Glibatec, R. M. Kannan, M. Lieh.Lai and D.J.P. Bassett. Dynamics of cellular entry and drug delivery by dentritic polymers into human lung epithelial carcinoma cells. J. Biomaterial Sci. Polymer Edn. 15: 311-330, 2004.
H. Rossmoore, L. Rossmoore and D.J.P. Bassett. Life and death of mycobacteria in the metal working environment. Lubes and Greases 20: 20-27, 2004.
air pollutant exposure on lungs
1. Examination of the effects of air pollutant exposure on lungs at different stages of airway remodeling associated with the development of chronic asthma – in collaboration with Susan Wilson, Ph.D. Southampton University, UK.;
development of hypersensitivity pneumonitis
2. Establishment of the risk factors associated with the development of hypersensitivity pneumonitis observed in machinists following exposure to microbial contaminated metal working fluids – being developed in collaboration with Biosan, Inc. Warren, MI
inflammatory lung models
3. Development and application of inflammatory lung models for use in the evaluation of new drug delivery systems based on nano-technology – in support of projects led by Mary Lieh-Lai, M.D., and R. Kannan, Ph.D., of the Wayne State University Departments of Paediatric Medicine and Chemical Engineering and Material Sciences, respectively.